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N3-PEG3-VC-PAB-MMAF

Catalog No.: A41445
Drug-Linker Conjugates For ADC
N3-PEG3-VC-PAB-MMAF is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, featuring a potent tubulin inhibitor, MMAF, linked via the N3-PEG3-VC-PAB moiety. This compound serves as a click chemistry reagent, facilitating the copper-catalyzed azide-alkyne cycloaddition (CuAAc) reaction with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-functionalized compounds, making it valuable for targeted drug delivery and therapeutic development in cancer research.
N3-PEG3-VC-PAB-MMAF 2757277-32-8 Drug-Linker Conjugates For ADC
Grouped product items
Size Price Stock Qty
5mg
$765.00
In stock
10mg
$1,175.00
In stock
25mg
$1,880.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionN3-PEG3-VC-PAB-MMAF is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, featuring a potent tubulin inhibitor, MMAF, linked via the N3-PEG3-VC-PAB moiety. This compound serves as a click chemistry reagent, facilitating the copper-catalyzed azide-alkyne cycloaddition (CuAAc) reaction with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-functionalized compounds, making it valuable for targeted drug delivery and therapeutic development in cancer research.
Product Information
Catalog NumA41445
FormulaC66H105N13O17
Molecular Weight1352.62
CAS Number2757277-32-8
SMILESOC([C@H](CC1=CC=CC=C1)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(COCCOCCOCCN=[N+]=[N-])=O)=O)=O)=O)=O)=O)=O)OC)=O)=O
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC