Nilotinib (AMN-107)

Catalog No.: A10644

Bcr-Abl inhibitor

Nilotinib (AMN-107) Chemical Structure

CAS NO. 641571-10-0

Nilotinib is a Bcr-Abl inhibitor with IC50 less than 30 nM.

Availability: In stock

Package Price Qty
100 mg

Regular Price: $30.00

Special Price $24.00

200 mg

Regular Price: $50.00

Special Price $40.00

10mM * 1mL in DMSO
$72.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Nilotinib is a Bcr-Abl inhibitor with IC50 less than 30 nM.
Targets
Bcr-Abl (Murine myeloid progenitor cells)
<30 nM
In vitro (25°C) DMSO 27 mg/mL (50.98 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.89 mL 94.43 mL 188.86 mL
0.5 mM 3.78 mL 18.89 mL 37.77 mL
1 mM 1.89 mL 9.44 mL 18.89 mL
5 mM 0.38 mL 1.89 mL 3.78 mL

*The above data is based on the productmolecular weight 529.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10644
Actions Inhibitor
M. Wt 529.5
Formula C28H22F3N7O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 641571-10-0
Synonyms AMN107
SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)N3C=C(N=C3)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CC=C5

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