NQDI 1 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50 = 3 μM, Ki = 500 nM).
Targets
Target
Value
Product Information
Catalog Num
A12838
Formula
C19H13NO4
Molecular Weight
319.31
CAS Number
175026-96-7
SMILES
O=C1NC2=CC=CC3=C2C(C4=CC=CC=C4C3=O)=C1C(OCC)=O
Synonyms
NQDI-1, NQDI1
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Solubility
In vitro (25°C)
DMSO
20 mg/mL (62.63 mM)
Water
Insoluble
Ethanol
Insoluble
In vivo
5%dmso+40%PEG300+5%tween-80+ddH2O
0.4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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