NSC59984

Catalog No.: A13413

P53 Activator

NSC59984

NSC59984 Chemical Structure

CAS NO. 803647-40-7

NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 uM for p53-null HCT116 cells.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $110.00

Special Price $88.00

10 mg

Regular Price: $190.00

Special Price $152.00

25 mg

Regular Price: $400.00

Special Price $320.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 uM for p53-null HCT116 cells.
Targets
p53
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 37.7 mL 188.49 mL 376.97 mL
0.5 mM 7.54 mL 37.7 mL 75.39 mL
1 mM 3.77 mL 18.85 mL 37.7 mL
5 mM 0.75 mL 3.77 mL 7.54 mL

*The above data is based on the productmolecular weight 265.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A13413
Actions Activator
M. Wt 265.27
Formula C12H15N3O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 803647-40-7
Synonyms NSC 59984, NSC-59984
SMILES CN1CCN(CC1)C(=O)C=CC2=CC=C(O2)[N+](=O)[O-]

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