Biological Activity
NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 uM for p53-null HCT116 cells.
Targets
p53 | ||||
In vitro | DMSO | 48 mg/mL (180.94 mM) | |
Water | Insoluble | ||
Ethanol | 48 mg/mL (180.94 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 37.7 mL | 188.49 mL | 376.97 mL |
0.5 mM | 7.54 mL | 37.7 mL | 75.39 mL |
1 mM | 3.77 mL | 18.85 mL | 37.7 mL |
5 mM | 0.75 mL | 3.77 mL | 7.54 mL |
*The above data is based on the productmolecular weight 265.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A13413 |
---|---|
Actions | Activator |
CAS No. | 803647-40-7 |
Formula | C12H15N3O4 |
M. Wt | 265.27 |
Solubility | DMSO |
Purity | >98% |
Synonyms | NSC 59984, NSC-59984 |
SMILES | CN1CCN(CC1)C(=O)C=CC2=CC=C(O2)[N+](=O)[O-] |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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