NSC59984

Name: NSC59984
Brand: Adooq Bioscience
SKU: A13413
Rating: 100 (268 reviews)

Catalog No.: A13413

P53 Activator

NSC59984 Chemical Structure

CAS NO. 803647-40-7

NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 uM for p53-null HCT116 cells.

Availability: In stock

Package	Price	Qty
5 mg	$110.00
10 mg	$190.00
25 mg	$400.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

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Biological Activity

Targets

p53

Solubility *

In vitro	DMSO	48 mg/mL (180.94 mM)
	Water	Insoluble
	Ethanol	48 mg/mL (180.94 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	37.7 mL	188.49 mL	376.97 mL
0.5 mM	7.54 mL	37.7 mL	75.39 mL
1 mM	3.77 mL	18.85 mL	37.7 mL
5 mM	0.75 mL	3.77 mL	7.54 mL

*The above data is based on the productmolecular weight 265.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A13413
Actions	Activator
CAS No.	803647-40-7
Formula	C12H15N3O4
M. Wt	265.27
Solubility	DMSO
Purity	>98%
Synonyms	NSC 59984, NSC-59984
SMILES	CN1CCN(CC1)C(=O)C=CC2=CC=C(O2)[N+](=O)[O-]
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.