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NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 uM for p53-null HCT116 cells.
Targets
| p53 | ||||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 37.7 mL | 188.49 mL | 376.97 mL |
| 0.5 mM | 7.54 mL | 37.7 mL | 75.39 mL |
| 1 mM | 3.77 mL | 18.85 mL | 37.7 mL |
| 5 mM | 0.75 mL | 3.77 mL | 7.54 mL |
*The above data is based on the productmolecular weight 265.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A13413 |
|---|---|
| Actions | Activator |
| M. Wt | 265.27 |
| Formula | C12H15N3O4 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 803647-40-7 |
| Synonyms | NSC 59984, NSC-59984 |
| SMILES | CN1CCN(CC1)C(=O)C=CC2=CC=C(O2)[N+](=O)[O-] |
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