NSC59984

Catalog No.: A13413

P53 Activator

NSC59984

NSC59984 Chemical Structure

CAS NO. 803647-40-7

NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 uM for p53-null HCT116 cells.

Availability: In stock

Package Price Qty
5 mg
$110.00
10 mg
$190.00
25 mg
$400.00
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Biological Activity

NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 uM for p53-null HCT116 cells.
Targets
p53
In vitro DMSO 48 mg/mL (180.94 mM)
Water Insoluble
Ethanol 48 mg/mL (180.94 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 37.7 mL 188.49 mL 376.97 mL
0.5 mM 7.54 mL 37.7 mL 75.39 mL
1 mM 3.77 mL 18.85 mL 37.7 mL
5 mM 0.75 mL 3.77 mL 7.54 mL

*The above data is based on the productmolecular weight 265.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13413
Actions Activator
CAS No. 803647-40-7
Formula C12H15N3O4
M. Wt 265.27
Solubility DMSO
Purity >98%
Synonyms NSC 59984, NSC-59984
SMILES CN1CCN(CC1)C(=O)C=CC2=CC=C(O2)[N+](=O)[O-]
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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