Nutlin 3a

Name: Nutlin 3a
Brand: Adooq Bioscience
SKU: A11501
Rating: 100 (3 reviews)

Catalog No.: A11501

MDM2 inhibitor

Product Citations (3)

Nutlin 3a Chemical Structure

CAS NO. 675576-98-4

Nutlin 3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53.

Availability: In stock

Package	Price	Qty
5 mg	$70.00
10 mg	$120.00
25 mg	$220.00
50 mg	$380.00
10mM * 1mL in DMSO	$140.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq Nutlin 3a

Sho Watanabe, .et al. Schlafen 11 is a novel target for mucosal regeneration in Ulcerative Colitis, J Crohns Colitis, 2021, Feb 17 PMID: 33596306
Shun Zhang, .et al. Sensitization of Gastric Cancer Cells to Irinotecan by p53 Activation, BPB Reports, 2019, 2, 130-133
Momoko Ishimine, .et al. The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer, Dis Markers, 2018, 2018: 5280736 PMID: 29651325

Biological Activity

Targets

p53/MDM2 interaction (Cell-free assay)
90 nM

Solubility *

In vitro (25°C)	DMSO	98 mg/mL (168.53 mM)
	Water	Insoluble
	Ethanol	98 mg/mL
In vivo	5% DMSO+55% PEG 300+ddH2O	7 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.2 mL	85.99 mL	171.97 mL
0.5 mM	3.44 mL	17.2 mL	34.39 mL
1 mM	1.72 mL	8.6 mL	17.2 mL
5 mM	0.34 mL	1.72 mL	3.44 mL

*The above data is based on the productmolecular weight 581.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11501
Actions	Inhibitor
CAS No.	675576-98-4
Formula	C30H30Cl2N4O4
M. Wt	581.49
Purity	>98%
Synonyms	Nutlin-3a, (-)-Nutlin-3
SMILES	CC(C)OC1=C(C=CC(=C1)OC)C2=N[[email protected]]([[email protected]](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.