Nutlin 3a

Catalog No.: A11501

MDM2 inhibitor

Nutlin 3a Chemical Structure

CAS NO. 675576-98-4

Nutlin 3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$120.00
25 mg
$220.00
50 mg
$380.00
10mM * 1mL in DMSO
$140.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Nutlin 3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53.
Targets
p53/MDM2 interaction (Cell-free assay)
90 nM
In vitro (25°C) DMSO 100 mg/mL (171.97 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (171.97 mM)
In vivo 2% DMSO/1% hydroxyethyl cellulose/0.2% Tween 80 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.2 mL 85.99 mL 171.97 mL
0.5 mM 3.44 mL 17.2 mL 34.39 mL
1 mM 1.72 mL 8.6 mL 17.2 mL
5 mM 0.34 mL 1.72 mL 3.44 mL

*The above data is based on the productmolecular weight 581.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11501
Actions Inhibitor
M. Wt 581.49
Formula C30H30Cl2N4O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 675576-98-4
Synonyms Nutlin-3a, (-)-Nutlin-3
SMILES CC(C)OC1=C(C=CC(=C1)OC)C2=N[[email protected]]([[email protected]](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

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