Total item
Cart Subtotal
$0.00 Biological Activity
Nutlin 3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53.
Targets
| p53/MDM2 interaction (Cell-free assay) | ||||
| 90 nM |
| In vitro (25°C) | DMSO | 100 mg/mL (171.97 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 100 mg/mL (171.97 mM) | ||
| In vivo | 2% DMSO/1% hydroxyethyl cellulose/0.2% Tween 80 | 15 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.2 mL | 85.99 mL | 171.97 mL |
| 0.5 mM | 3.44 mL | 17.2 mL | 34.39 mL |
| 1 mM | 1.72 mL | 8.6 mL | 17.2 mL |
| 5 mM | 0.34 mL | 1.72 mL | 3.44 mL |
*The above data is based on the productmolecular weight 581.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11501 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 581.49 |
| Formula | C30H30Cl2N4O4 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 675576-98-4 |
| Synonyms | Nutlin-3a, (-)-Nutlin-3 |
| SMILES | CC(C)OC1=C(C=CC(=C1)OC)C2=N[[email protected]]([[email protected]](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl |
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
NSC-207895 (XI-006)
NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A…
AMG232
AMG 232 is a highly potent, selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction((SPR KD= 0.045 nM, SJSA-1 E…
Idasanutlin (RG7388)
Idasanutlin is a potent and selective p53-MDM2 inhibitor.
RG7112
RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.
MDM2 Inhibitor
MDM2 Inhibitor is a cell-permeable boranyl-chalcone exhibiting strong binding to MDM2 and irreversibly disrupts the MDM2/p53 protein complex…
SJ 172550
SJ 172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the…
Nutlin-3
MDM2 antagonist nutlin-3 is a potent inducer of apoptosis.
p53 and MDM2 proteins-interaction-inhibitor chiral
p53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins.
Keywords:buy Nutlin 3a | Nutlin 3a Supplier | purchase Nutlin 3a | Nutlin 3a cost | Nutlin 3a manufacturer | order Nutlin 3a | Nutlin 3a distributor | buy 675576-98-4| 675576-98-4 Supplier | purchase 675576-98-4 | 675576-98-4 cost | 675576-98-4 manufacturer | order 675576-98-4 | 675576-98-4 distributor
Contact information
United StatesAdooq Bioscience
Toll Free: (866) 930-6790
Fax: +1-323-606-8156
Email: [email protected]
Not your Region? View all Distributors
Adooq Quality Guarantee
We promise all products perform as described.