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$0.00 - Shun Zhang, .et al. Sensitization of Gastric Cancer Cells to Irinotecan by p53 Activation, BPB Reports, 2019, 2, 130-133
- Momoko Ishimine, .et al. The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer, Dis Markers, 2018, 2018: 5280736 PMID: 29651325
Biological Activity
Nutlin 3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53.
Targets
| p53/MDM2 interaction (Cell-free assay) | ||||
| 90 nM |
| In vitro (25°C) | DMSO | 100 mg/mL (171.97 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 100 mg/mL (171.97 mM) | ||
| In vivo | 2% DMSO/1% hydroxyethyl cellulose/0.2% Tween 80 | 15 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.2 mL | 85.99 mL | 171.97 mL |
| 0.5 mM | 3.44 mL | 17.2 mL | 34.39 mL |
| 1 mM | 1.72 mL | 8.6 mL | 17.2 mL |
| 5 mM | 0.34 mL | 1.72 mL | 3.44 mL |
*The above data is based on the productmolecular weight 581.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11501 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 581.49 |
| Formula | C30H30Cl2N4O4 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 675576-98-4 |
| Synonyms | Nutlin-3a, (-)-Nutlin-3 |
| SMILES | CC(C)OC1=C(C=CC(=C1)OC)C2=N[[email protected]]([[email protected]](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl |
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