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VEGFR inhibitor

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Catalog No. A12693

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
NVP-BAW2881 5mg A12693-5

Regular Price: €85.50

Special Price: €76.95

NVP-BAW2881 10mg A12693-10

Regular Price: €171.00

Special Price: €153.90

NVP-BAW2881 25mg A12693-25

Regular Price: €323.00

Special Price: €290.70

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

NVP-BAW2881 is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation.


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Chemical Information

Catalog Num A12693
Actions Inhibitor
M. Wt 424.1147
Formula C22H15F3N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 861875-60-7
Synonyms BAW2881, BAW-2881, BAW 2881, NVP-BAW-2881, NVP-BAW 2881
SMILES code O=C(NC1=CC(C(F)(F)F)=CC=C1)C2=CC=CC3=C2C=CC(OC4=CC=NC(N)=N4)=C3
Chemical Name 6-((2-aminopyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide

Biological Activity

NVP-BAW2881 is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation.
Target Value
hVEGFR2IC50: 9nM
C-Raf-1IC50: 24nM
B-RAFV599EIC50: 76nM
c-AblIC50: 99nM
mVEGF2IC50: 165nM
RETIC50: 410nM
hVEGFR3IC50: 420nM
hVEGFR1IC50: 820nM
c-KITIC50: 2.5μM

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.58 mL 117.89 mL 235.79mL
0.5 mM 4.72 mL 23.58 mL 47.16 mL
1 mM 2.36 mL 11.79 mL 23.58 mL
5 mM 0.47 mL 2.36 mL 4.72 mL

*The above data is based on the productmolecular weight 424.1147. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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