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NVP-BAW2881 is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation.
Targets
| Target | Value | |
|---|---|---|
| TIE-2 | ||
| hVEGFR2 | IC50: 9nM | |
| C-Raf-1 | IC50: 24nM | |
| B-RAFV599E | IC50: 76nM | |
| c-Abl | IC50: 99nM | |
| mVEGF2 | IC50: 165nM | |
| RET | IC50: 410nM | |
| hVEGFR3 | IC50: 420nM | |
| hVEGFR1 | IC50: 820nM | |
| c-KIT | IC50: 2.5μM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.58 mL | 117.89 mL | 235.79 mL |
| 0.5 mM | 4.72 mL | 23.58 mL | 47.16 mL |
| 1 mM | 2.36 mL | 11.79 mL | 23.58 mL |
| 5 mM | 0.47 mL | 2.36 mL | 4.72 mL |
*The above data is based on the productmolecular weight 424.1147. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A12693 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 424.1147 |
| Formula | C22H15F3N4O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 861875-60-7 |
| Synonyms | BAW2881, BAW-2881, BAW 2881, NVP-BAW-2881, NVP-BAW 2881 |
| SMILES | O=C(NC1=CC(C(F)(F)F)=CC=C1)C2=CC=CC3=C2C=CC(OC4=CC=NC(N)=N4)=C3 |
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