Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order
Biological Activity
NVP-BAW2881 is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation.
Targets
Target | Value | |
---|---|---|
TIE-2 | ||
hVEGFR2 | IC50: 9nM | |
C-Raf-1 | IC50: 24nM | |
B-RAFV599E | IC50: 76nM | |
c-Abl | IC50: 99nM | |
mVEGF2 | IC50: 165nM | |
RET | IC50: 410nM | |
hVEGFR3 | IC50: 420nM | |
hVEGFR1 | IC50: 820nM | |
c-KIT | IC50: 2.5μM |
In vitro | DMSO | 76 mg/mL (179.08 mM) | |
Water | Insoluble | ||
Ethanol | 18 mg/mL | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 23.58 mL | 117.89 mL | 235.79 mL |
0.5 mM | 4.72 mL | 23.58 mL | 47.16 mL |
1 mM | 2.36 mL | 11.79 mL | 23.58 mL |
5 mM | 0.47 mL | 2.36 mL | 4.72 mL |
*The above data is based on the productmolecular weight 424.1147. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A12693 |
---|---|
Actions | Inhibitor |
CAS No. | 861875-60-7 |
Formula | C22H15F3N4O2 |
M. Wt | 424.1147 |
Purity | >98% |
Synonyms | BAW2881, BAW-2881, BAW 2881, NVP-BAW-2881, NVP-BAW 2881 |
SMILES | O=C(NC1=CC(C(F)(F)F)=CC=C1)C2=CC=CC3=C2C=CC(OC4=CC=NC(N)=N4)=C3 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
Vandetanib (ZD6474)
Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9…
Telatinib (BAY 57-9352)
Telatinib (BAY 57-9352) is an orally available, small-molecule inhibitor of vascular endothelial growth factor receptors 2 and 3 (VEGFR-2/-3…
CP-547632
CP-547632 is a novel, potent vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor
TSU-68 (Orantinib, SU6668)
Orantinib (TSU-68, SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly in…
KRN 633
KRN 633 is a cell-permeable, reversible, ATP-competitive VEGFR kinase inhibitor that inhibits PDGFR-α and c-Kit at higher concentrations on…
TPT-260 (Dihydrochloride)
TPT-260 is a thiophene thiourea derivative.
Regorafenib (BAY 73-4506)
Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an ora…
Taxifolin
Taxifolin is found to bind at the ATP-binding site on VEGFR-2 kinase with large value of binding energy and act as type I competitive inhibi…
Keywords:buy NVP-BAW2881 | NVP-BAW2881 Supplier | purchase | cost | manufacturer | order | distributor | buy 861875-60-7| 861875-60-7 Supplier | purchase 861875-60-7 | 861875-60-7 cost | 861875-60-7 manufacturer | order 861875-60-7 | 861875-60-7 distributor