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Biological Activity
NVP-BAW2881 is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation.
Targets
| Target | Value | |
|---|---|---|
| TIE-2 | ||
| hVEGFR2 | IC50: 9nM | |
| C-Raf-1 | IC50: 24nM | |
| B-RAFV599E | IC50: 76nM | |
| c-Abl | IC50: 99nM | |
| mVEGF2 | IC50: 165nM | |
| RET | IC50: 410nM | |
| hVEGFR3 | IC50: 420nM | |
| hVEGFR1 | IC50: 820nM | |
| c-KIT | IC50: 2.5μM |
| In vitro | DMSO | 76 mg/mL (179.08 mM) | |
| Water | Insoluble | ||
| Ethanol | 18 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.58 mL | 117.89 mL | 235.79 mL |
| 0.5 mM | 4.72 mL | 23.58 mL | 47.16 mL |
| 1 mM | 2.36 mL | 11.79 mL | 23.58 mL |
| 5 mM | 0.47 mL | 2.36 mL | 4.72 mL |
*The above data is based on the productmolecular weight 424.1147. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12693 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 861875-60-7 |
| Formula | C22H15F3N4O2 |
| M. Wt | 424.1147 |
| Purity | >98% |
| Synonyms | BAW2881, BAW-2881, BAW 2881, NVP-BAW-2881, NVP-BAW 2881 |
| SMILES | O=C(NC1=CC(C(F)(F)F)=CC=C1)C2=CC=CC3=C2C=CC(OC4=CC=NC(N)=N4)=C3 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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