NVP-TAE 226

Catalog No.: A11507

FAK inhibitor

NVP-TAE 226

NVP-TAE 226 Chemical Structure

CAS NO. 761437-28-9

NVP-TAE226 is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2(IC50=3.5 nM); 10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $100.00

Special Price $90.00

10 mg

Regular Price: $180.00

Special Price $162.00

25 mg

Regular Price: $320.00

Special Price $288.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

NVP-TAE226 is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2(IC50=3.5 nM); 10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met.
Targets
Target Value
PYK2IC50: 3.5nM
FAKIC50: 5.5nM
Insulin ReceptorIC50: 43.5nM
IGF-1RIC50: 140nM
c-MetIC50: 160nM
FLT4IC50: 220nM
KDRIC50: 360nM
FLT3IC50: 480nM
CDK1/CyclinBIC50: 540nM
TekIC50: 580nM
FGFR3(K650E)IC50: 630nM
FGFR1IC50: 750nM
JAK2IC50: 840nM
c-SrcIC50: 905nM
HER2IC50: 945nM
RETIC50: 1.3μM
HER1IC50: 1.7μM
RET(M918T)IC50: 2.3μM
PDK-1IC50: 2.4μM
PDGFRβIC50: 2.6μM
FLT1IC50: 3.4μM
c-AblIC50: 5.85μM
ZAP70IC50: 7.7μM
SykIC50: 7.9μM
PKAIC50: >10μM
PKBIC50: >10μM
C-RafIC50: >10μM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.32 mL 106.62 mL 213.25 mL
0.5 mM 4.26 mL 21.32 mL 42.65 mL
1 mM 2.13 mL 10.66 mL 21.32 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

*The above data is based on the productmolecular weight 468.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A11507
Actions Inhibitor
M. Wt 468.94
Formula C23H25ClN6O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 761437-28-9
Synonyms TAE226, TAE 226
SMILES CNC(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCOCC4)OC

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