O-Carboranylphenoxyacetanilide functions as a HIF-1α inhibitor, effectively blocking the activation of HIF-1α. This compound demonstrates significant inhibition of HIF transcriptional activity in HeLa cells, with an IC50 value of 0.74 μM. Additionally, O-Carboranylphenoxyacetanilide targets HSP60, impairing both its chaperone and ATPase activities, making it a valuable reagent for research on hypoxia-regulated pathways and cellular stress responses.
O-Carboranylphenoxyacetanilide functions as a HIF-1α inhibitor, effectively blocking the activation of HIF-1α. This compound demonstrates significant inhibition of HIF transcriptional activity in HeLa cells, with an IC50 value of 0.74 μM. Additionally, O-Carboranylphenoxyacetanilide targets HSP60, impairing both its chaperone and ATPase activities, making it a valuable reagent for research on hypoxia-regulated pathways and cellular stress responses.
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