OSI-930

Name: OSI-930
SKU: A10679

Catalog No.: A10679

c-Kit/VEGFR Inhibitor

OSI-930

OSI-930 Chemical Structure

CAS NO. 728033-96-3

OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively.

Availability: In stock

Package	Price	Qty
5 mg	Regular Price: $90.00 Special Price $72.00
25 mg	Regular Price: $200.00 Special Price $160.00
50 mg	Regular Price: $350.00 Special Price $280.00
100 mg	Regular Price: $600.00 Special Price $480.00
10mM * 1mL in DMSO	$139.00

Price Match Request

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable papers

Nature 2017
551, 247-250

Science
2017; 356(6336)

Nat Chem Biol.
1, 713–720 (2015)

Nat Commun
2016; 7: 11051.

Nat Cell Biol. 2013
15(12):1473-85.

Cell 2014 Feb 27
156(5):986-1001.

Nat Commun
2015; 6: 7139.

PNAS 2014
111(43) 15514-15519

PNAS 2014
111(23) E2404-E2413

J Neurosci. 2015
35(5): 2101–2111

Scientific Reports
5, 12298.

Cell Research
225, 707–725.

Oncogene
2014, 1–14 .

Details

Biological Activity

OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively.

Targets

Target	Value
FLT1	IC50: 8nM
KDR	IC50: 9nM
CSF-1R	IC50: 15nM
LCK	IC50: 22nM
C-Raf	IC50: 41nM
Kit	IC50: 80nM
FLT3	IC50: 1.303μM
PDGFRα	IC50: 3.408μM
Abl	IC50: 4.738μM
PDGFRβ	IC50: 6.9μM
EGFR	IC50: >10μM
AuroraA	IC50: >10μM
Axl	IC50: >10μM
CDK2/CyclinA	IC50: >10μM
IKKβ	IC50: >10μM
MEK1	IC50: >10μM
PDPK1	IC50: >10μM
PKBβ	IC50: >10μM
Tie-2	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	89 mg/mL (200.7 mM)
	Water	<1 mg/mL (<1 mM)
	Ethanol	3 mg/mL (6.76 mM)
In vivo	30% PEG400/0.5% Tween80/5% propylene glycol	5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.55 mL	112.76 mL	225.53 mL
0.5 mM	4.51 mL	22.55 mL	45.11 mL
1 mM	2.26 mL	11.28 mL	22.55 mL
5 mM	0.45 mL	2.26 mL	4.51 mL

*The above data is based on the productmolecular weight 443.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num	A10679
Actions	Inhibitor
M. Wt	443.4
Formula	C22H16F3N3O2S
Solubility	DMSO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	728033-96-3
Synonyms	OSI930
SMILES	C1=CC=C2C(=C1)C(=CC=N2)CNC3=C(SC=C3)C(=O)NC4=CC=C(C=C4)OC(F)(F)F