OSI-930

Catalog No.: A10679

c-Kit/VEGFR Inhibitor

OSI-930 Chemical Structure

CAS NO. 728033-96-3

OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively.

Availability: In stock

Package Price Qty
5 mg
$90.00
25 mg
$200.00
50 mg
$350.00
100 mg
$600.00
10mM * 1mL in DMSO
$139.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively.
Targets
Target Value
FLT1IC50: 8nM
KDRIC50: 9nM
CSF-1RIC50: 15nM
LCKIC50: 22nM
C-RafIC50: 41nM
KitIC50: 80nM
FLT3IC50: 1.303μM
PDGFRαIC50: 3.408μM
AblIC50: 4.738μM
PDGFRβIC50: 6.9μM
EGFRIC50: >10μM
AuroraAIC50: >10μM
AxlIC50: >10μM
CDK2/CyclinAIC50: >10μM
IKKβIC50: >10μM
MEK1IC50: >10μM
PDPK1IC50: >10μM
PKBβIC50: >10μM
Tie-2IC50: >10μM
In vitro (25°C) DMSO 89 mg/mL (200.7 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (6.76 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.55 mL 112.76 mL 225.53 mL
0.5 mM 4.51 mL 22.55 mL 45.11 mL
1 mM 2.26 mL 11.28 mL 22.55 mL
5 mM 0.45 mL 2.26 mL 4.51 mL

*The above data is based on the productmolecular weight 443.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10679
Actions Inhibitor
M. Wt 443.4
Formula C22H16F3N3O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 728033-96-3
Synonyms OSI930
SMILES C1=CC=C2C(=C1)C(=CC=N2)CNC3=C(SC=C3)C(=O)NC4=CC=C(C=C4)OC(F)(F)F

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