Biological Activity
OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively.
Targets
Target | Value |
---|---|
FLT1 | IC50: 8nM |
KDR | IC50: 9nM |
CSF-1R | IC50: 15nM |
LCK | IC50: 22nM |
C-Raf | IC50: 41nM |
Kit | IC50: 80nM |
FLT3 | IC50: 1.303μM |
PDGFRα | IC50: 3.408μM |
Abl | IC50: 4.738μM |
PDGFRβ | IC50: 6.9μM |
EGFR | IC50: >10μM |
AuroraA | IC50: >10μM |
Axl | IC50: >10μM |
CDK2/CyclinA | IC50: >10μM |
IKKβ | IC50: >10μM |
MEK1 | IC50: >10μM |
PDPK1 | IC50: >10μM |
PKBβ | IC50: >10μM |
Tie-2 | IC50: >10μM |
In vitro (25°C) | DMSO | 85 mg/mL (191.68 mM) | |
Water | Insoluble | ||
Ethanol | 3 mg/mL | ||
In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 4 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 22.55 mL | 112.76 mL | 225.53 mL |
0.5 mM | 4.51 mL | 22.55 mL | 45.11 mL |
1 mM | 2.26 mL | 11.28 mL | 22.55 mL |
5 mM | 0.45 mL | 2.26 mL | 4.51 mL |
*The above data is based on the productmolecular weight 443.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10679 |
---|---|
Actions | Inhibitor |
CAS No. | 728033-96-3 |
Formula | C22H16F3N3O2S |
M. Wt | 443.4 |
Purity | >98% |
Synonyms | OSI930 |
SMILES | C1=CC=C2C(=C1)C(=CC=N2)CNC3=C(SC=C3)C(=O)NC4=CC=C(C=C4)OC(F)(F)F |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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