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P5(PEG12)-VC-PAB-Exatecan

Catalog No.: A41594
Drug-linker Conjugate for ADC
P5(PEG12)-VC-PAB-Exatecan is a drug-linker conjugate designed for use in antibody-drug conjugates (ADCs), targeting the DNA topoisomerase I enzyme. This compound combines the potent antitumor activity of Exatecan with the cleavable linker P5(PEG12)-VC-PAB, providing a targeted approach to cancer therapy. It serves as a valuable tool for research applications focused on tumor treatment and the mechanism of ADC efficacy.
P5(PEG12)-VC-PAB-Exatecan 2928571-52-0 Drug-linker Conjugate for ADC
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionP5(PEG12)-VC-PAB-Exatecan is a drug-linker conjugate designed for use in antibody-drug conjugates (ADCs), targeting the DNA topoisomerase I enzyme. This compound combines the potent antitumor activity of Exatecan with the cleavable linker P5(PEG12)-VC-PAB, providing a targeted approach to cancer therapy. It serves as a valuable tool for research applications focused on tumor treatment and the mechanism of ADC efficacy.
Product Information
Catalog NumA41594
FormulaC76H103FN9O24P
Molecular Weight1576.65
CAS Number2928571-52-0
SMILESO=C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C1)=CC=C1COC(N[C@H]2CCC3=C4C2=C5C(C(N6C5)=CC([C@](CC)(O)C(OC7)=O)=C7C6=O)=NC4=CC(F)=C3C)=O)=O)=O)C8=CC=C(NP(C#C)(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)=O)C=C8
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC