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- Li T,et al. Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma, Oncogene, 2018, Nov;37(47):6180-6194 30013190
|Storage||at -20°C 3 years Powder|
|SMILES code||CC(=O)O.C1CC[[email protected]]([[email protected]](C1)N)NC2=NC=C(C(=N2)NC3=CC=CC(=C3)N4N=CC=N4)C(=O)N|
|Chemical Name||4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1R,2S)-2-aminocyclohexylamino) pyrimidine-5-carboxamide|
|P505-15 (also known as PRT062607) is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases.|
|Solubility (25°C) *||In vitro||DMSO||86 mg/mL (200.04 mM)|
|Water||86 mg/mL (200.04 mM)|
|Ethanol||<1 mg/mL (<1 mM)|
|In vivo||Saline||30 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||25.42 mL||127.08 mL||254.16mL|
|0.5 mM||5.08 mL||25.42 mL||50.83 mL|
|1 mM||2.54 mL||12.71 mL||25.42 mL|
|5 mM||0.51 mL||2.54 mL||5.08 mL|
*The above data is based on the productmolecular weight 393.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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