Pavurutamab (AMG-701) is a bispecific T-cell engager that targets both CD3 on T-cells and B-cell maturation antigens (BCMA) on plasma cells. This molecule is engineered with an extended half-life derivative of Pacanalotamab, enhancing its stability and duration of action. The Fc region of Pavurutamab has been modified to incorporate molecules that optimize its pharmacokinetic properties, ensuring sustained efficacy. This biologic is primarily investigated for its potential therapeutic applications in the modulation of immune responses and as a treatment for multiple myeloma (MM).
Pavurutamab (AMG-701) is a bispecific T-cell engager that targets both CD3 on T-cells and B-cell maturation antigens (BCMA) on plasma cells. This molecule is engineered with an extended half-life derivative of Pacanalotamab, enhancing its stability and duration of action. The Fc region of Pavurutamab has been modified to incorporate molecules that optimize its pharmacokinetic properties, ensuring sustained efficacy. This biologic is primarily investigated for its potential therapeutic applications in the modulation of immune responses and as a treatment for multiple myeloma (MM).
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
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Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
Frequently Asked Questions
What are Biosimilar Antibodies?
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research.
Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
