Pazopanib (GW-786034)

Name: Pazopanib (GW-786034)
Brand: Adooq Bioscience
SKU: A11518
Rating: 100 (3 reviews)

Catalog No.: A11518

VEGFR inhibitor

Product Citations (3)

Pazopanib (GW-786034) Chemical Structure

CAS NO. 444731-52-6

Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.

Availability: In stock

Package	Price	Qty
25 mg	$45.00
50 mg	$78.00
100 mg	$135.00
10mM * 1mL in DMSO	$50.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq Pazopanib (GW-786034)

Koide H, .et al. Substrate-dependent effects of molecular-targeted anticancer agents on activity of organic anion transporting polypeptide 1B1, Xenobiotica, 2018, Oct;48(10):1059-1071 PMID: 29034773
Ellawatty WEA, .et al. Organic cation transporter 1 is responsible for hepatocellular uptake of the tyrosine kinase inhibitor pazopanib, Drug Metab Dispos, 2018, Jan;46(1):33-40 PMID: 29089306
Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

Biological Activity

Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.

Targets

Target	Value
VEGFR1	IC50: 10nM
VEGFR2	IC50: 30nM
VEGFR3	IC50: 47nM
FGFR	IC50: 74nM
PDGFR	IC50: 84nM
c-Kit	IC50: 140nM
c-Fms	IC50: 146nM

Solubility *

In vitro	DMSO	Warmed: 84 mg/mL (191.98 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.86 mL	114.29 mL	228.57 mL
0.5 mM	4.57 mL	22.86 mL	45.71 mL
1 mM	2.29 mL	11.43 mL	22.86 mL
5 mM	0.46 mL	2.29 mL	4.57 mL

*The above data is based on the productmolecular weight 437.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11518
Actions	Inhibitor
CAS No.	444731-52-6
Formula	C21H23N7O2S
M. Wt	437.5
Purity	>98%
Synonyms	GW 786034, Votrient,GW786034
SMILES	CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.