PD173955

Catalog No.: A13120

Bcr-Abl inhibitor

PD173955

PD173955 Chemical Structure

CAS NO. 260415-63-2

PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G(1). PD173955 has an IC(50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand-dependent c-kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC(50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC(50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC(50) = 1 microM)-dependent cell growth.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $120.00

Special Price $108.00

10 mg

Regular Price: $200.00

Special Price $180.00

25 mg

Regular Price: $350.00

Special Price $315.00

50 mg

Regular Price: $600.00

Special Price $540.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G(1). PD173955 has an IC(50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand-dependent c-kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC(50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC(50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC(50) = 1 microM)-dependent cell growth.
Targets
Bcr-Abl Src
1 nM-2 nM22 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.56 mL 112.78 mL 225.56 mL
0.5 mM 4.51 mL 22.56 mL 45.11 mL
1 mM 2.26 mL 11.28 mL 22.56 mL
5 mM 0.45 mL 2.26 mL 4.51 mL

*The above data is based on the productmolecular weight 443.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13120
Actions Inhibitor
M. Wt 443.35
Formula C21H16Cl2N4OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 260415-63-2
Synonyms PD 173955; PD-173955
SMILES CN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=CC=C3Cl)Cl)NC4=CC(=CC=C4)SC

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