Total item
Cart Subtotal
$0.00 - Anderson SR, .et al. Developmental Apoptosis Promotes a Disease-Related Gene Signature and Independence from CSF1R Signaling in Retinal Microglia, Cell Rep, 2019, May 14;27(7):2002-2013.e5 PMID: 31091440
Biological Activity
Pexidartinib is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity.
Targets
| Kit | CSF-1R | Flt3 | ||
| 10 nM | 20 nM | 160 nM |
| In vitro (25°C) | DMSO | 71 mg/mL (169.93 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+45% PEG 300+5% Tween 80+ddH2O | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.93 mL | 119.67 mL | 239.34 mL |
| 0.5 mM | 4.79 mL | 23.93 mL | 47.87 mL |
| 1 mM | 2.39 mL | 11.97 mL | 23.93 mL |
| 5 mM | 0.48 mL | 2.39 mL | 4.79 mL |
*The above data is based on the productmolecular weight 417.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15520 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1029044-16-3 |
| Formula | C20H15ClF3N5 |
| M. Wt | 417.81 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | PLX-3397, PLX 3397 |
| SMILES | FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
INCB018424 (Ruxolitinib)
INCB018424 is a potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 …
CEP33779
CEP33779 is a selective JAK2 inhibitor with IC50 of 1.8 nM.
FLLL32
FLLL32 is a potent JAK2/STAT3 inhibitor with IC50 of
Cyt387 (Momelotinib)
CYT387 is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively.
TCS 359
TCS 359 is a potent inhibitor of FLT3 receptor tyrosine kinase (IC50 = 42 nM) that displays selectivity over a range of other kinases.
AG-490
AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Also inhib…
AMG-925
AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor.
BMS-911543
BMS-911543 is an orally available small molecule targeting a subset of Janus-associated kinase (JAK) with potential antineoplastic activity.…
Keywords:buy Pexidartinib (PLX3397) | Pexidartinib (PLX3397) Supplier | purchase | cost | manufacturer | order | distributor | buy 1029044-16-3| 1029044-16-3 Supplier | purchase 1029044-16-3 | 1029044-16-3 cost | 1029044-16-3 manufacturer | order 1029044-16-3 | 1029044-16-3 distributor
Adooq Quality Guarantee
We promise all products perform as described.