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Pexidartinib is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity.
Targets
| Kit | CSF-1R | Flt3 | ||
| 10 nM | 20 nM | 160 nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.93 mL | 119.67 mL | 239.34 mL |
| 0.5 mM | 4.79 mL | 23.93 mL | 47.87 mL |
| 1 mM | 2.39 mL | 11.97 mL | 23.93 mL |
| 5 mM | 0.48 mL | 2.39 mL | 4.79 mL |
*The above data is based on the productmolecular weight 417.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15520 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 417.81 |
| Formula | C20H15ClF3N5 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1029044-16-3 |
| Synonyms | PLX-3397, PLX 3397 |
| SMILES | FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F |
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