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FAK inhibitor

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Catalog No. A12580

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PF-00562271 5mg A12580-5
PF-00562271 10mg A12580-10
PF-00562271 25mg A12580-25
PF-00562271 50mg A12580-50
PF-00562271 10mM * 1mL in DMSO A12580-10mM-D

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively.


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Chemical Information

Catalog Num A12580
Actions Inhibitor
M. Wt 665.66
Formula C21H20F3N7O3S.C6H6O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 939791-38-5
Synonyms PF00562271, PF 00562271
SMILES CN(C1=C(C=CC=N1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C.C1=CC=C(C=C1)S(=O)(=O)O

Biological Activity

PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively.
Target Value
FAKIC50: 1.5nM
PYK2IC50: 13nM
CDK2/CyclinEIC50: 30nM
CDK3/CyclinEIC50: 47nM
CDK1/CyclinBIC50: 58nM
CDK7/CyclinH/MAT1IC50: 97nM
FLT3IC50: 97nM
GSK-3αIC50: 101nM
CDK5/p35IC50: 120nM
GSK-3βIC50: 133nM
AuroraAIC50: 145nM
CDK2/CyclinAIC50: 227nM
YESIC50: 294nM
MAPK1IC50: 340nM
FynIC50: 377nM
LCKIC50: 408nM
IGF-1RIC50: >500nM
PKAIC50: 620nM
c-SrcIC50: 797nM
CDK4IC50: >1μM
CDK6/CyclinD2IC50: >1μM
Chk1IC50: >1μM
Chk2IC50: >1μM
EGFRIC50: >1μM
EphB2IC50: >1μM
FGFR3IC50: >1μM
AblIC50: >1μM
FmsIC50: >1μM
IKKαIC50: >1μM
IKKβIC50: >1μM
JNK1α1IC50: >1μM
MEK1IC50: >1μM
p70S6KIC50: >1μM
PKBαIC50: >1μM
PKBβIC50: >1μM
PKBγIC50: >1μM
PKCαIC50: >1μM
PKCβ2IC50: >1μM
PKCδIC50: >1μM
TrkBIC50: >2.5μM
PDGFRβIC50: >3μM


Solubility (25°C)* In vitro DMSO 14 mg/mL heating (21.03 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.02 mL 75.11 mL 150.23mL
0.5 mM 3 mL 15.02 mL 30.05 mL
1 mM 1.5 mL 7.51 mL 15.02 mL
5 mM 0.3 mL 1.5 mL 3 mL

*The above data is based on the productmolecular weight 665.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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