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PF-00562271

Catalog No.: A12580

FAK inhibitor

PF-00562271

PF-00562271 Chemical Structure

CAS NO. 939791-38-5

PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$90.00
25 mg
$180.00
50 mg
$250.00
10mM * 1mL in DMSO
$103.00
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Biological Activity

PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively.
Targets
Target Value
FAKIC50: 1.5nM
PYK2IC50: 13nM
CDK2/CyclinEIC50: 30nM
CDK3/CyclinEIC50: 47nM
CDK1/CyclinBIC50: 58nM
CDK7/CyclinH/MAT1IC50: 97nM
FLT3IC50: 97nM
GSK-3αIC50: 101nM
CDK5/p35IC50: 120nM
GSK-3βIC50: 133nM
AuroraAIC50: 145nM
CDK2/CyclinAIC50: 227nM
YESIC50: 294nM
MAPK1IC50: 340nM
FynIC50: 377nM
LCKIC50: 408nM
IGF-1RIC50: >500nM
PKAIC50: 620nM
c-SrcIC50: 797nM
CDK4IC50: >1μM
CDK6/CyclinD2IC50: >1μM
Chk1IC50: >1μM
Chk2IC50: >1μM
EGFRIC50: >1μM
EphB2IC50: >1μM
FGFR3IC50: >1μM
AblIC50: >1μM
FmsIC50: >1μM
IKKαIC50: >1μM
IKKβIC50: >1μM
JNK1α1IC50: >1μM
MEK1IC50: >1μM
p70S6KIC50: >1μM
PKBαIC50: >1μM
PKBβIC50: >1μM
PKBγIC50: >1μM
PKCαIC50: >1μM
PKCβ2IC50: >1μM
PKCδIC50: >1μM
TrkBIC50: >2.5μM
PDGFRβIC50: >3μM
In vitro (25°C) DMSO Warmed: 14 mg/mL (21.03 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+30% PEG 300+ddH2O 2 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.02 mL 75.11 mL 150.23 mL
0.5 mM 3 mL 15.02 mL 30.05 mL
1 mM 1.5 mL 7.51 mL 15.02 mL
5 mM 0.3 mL 1.5 mL 3 mL

*The above data is based on the productmolecular weight 665.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12580
Actions Inhibitor
CAS No. 939791-38-5
Formula C21H20F3N7O3S.C6H6O3S
M. Wt 665.66
Purity >98%
Synonyms PF00562271, PF 00562271
SMILES CN(C1=C(C=CC=N1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C.C1=CC=C(C=C1)S(=O)(=O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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