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Biological Activity
PF-04217903 is a novel c-Met/hepatocyte growth factor receptor tyrosine kinase inhibitors.
Targets
| c-Met (A549 cells) | ||||
| 4.8 nM |
| In vitro (25°C) | DMSO | 5 mg/mL (13.42 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+30% PEG 300+2% Tween 80+ddH2O | 1 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.85 mL | 134.26 mL | 268.53 mL |
| 0.5 mM | 5.37 mL | 26.85 mL | 53.71 mL |
| 1 mM | 2.69 mL | 13.43 mL | 26.85 mL |
| 5 mM | 0.54 mL | 2.69 mL | 5.37 mL |
*The above data is based on the productmolecular weight 372.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10711 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 956905-27-4 |
| Formula | C19H16N8O |
| M. Wt | 372.4 |
| Purity | >98% |
| Synonyms | PF04217903 |
| SMILES | C1=CC2=C(C=CC(=C2)CN3C4=NC(=CN=C4N=N3)C5=CN(N=C5)CCO)N=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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