PF-06250112

Catalog No.: A18612

BTK inhibitor

PF-06250112

PF-06250112 Chemical Structure

CAS NO. 1609465-89-5

PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively.

Availability: In stock

Package Price Qty
5 mg
$140.00
10 mg
$240.00
50 mg
$920.00
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Biological Activity

PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.81 mL 114.04 mL 228.09 mL
0.5 mM 4.56 mL 22.81 mL 45.62 mL
1 mM 2.28 mL 11.4 mL 22.81 mL
5 mM 0.46 mL 2.28 mL 4.56 mL

*The above data is based on the productmolecular weight 438.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18612
Actions Inhibitor
M. Wt 438.43
Formula C22H20F2N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1609465-89-5
Synonyms PF06250112, PF 06250112
SMILES O=C(N)C1=C(N(N=C1C2=CC=C(C=C2)OC3=CC=C(C=C3F)F)[[email protected]@H]4CN(CCC4)C#N)N

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