PF-543

Catalog No.: A13039

SphK1 inhibitor

PF-543

PF-543 Chemical Structure

CAS NO. 1415562-82-1

PF-543 is a novel selective SK-1 inhibitor which inhibited SK-1 activity in a competitive manner with sphingosine.

Availability: In stock

Package Price Qty
10 mg
$150.00
25 mg
$300.00
50 mg
$500.00
10mM * 1mL in DMSO
$129.00
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Biological Activity

PF-543 is a novel selective SK-1 inhibitor which inhibited SK-1 activity in a competitive manner with sphingosine.
Targets
SphK1 SphK1
2.0 nM3.6 nM(Ki)
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.48 mL 107.39 mL 214.78 mL
0.5 mM 4.3 mL 21.48 mL 42.96 mL
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

*The above data is based on the productmolecular weight 465.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13039
Actions Inhibitor
CAS No. 1415562-82-1
Formula C27H31NO4S
M. Wt 465.6
Purity >98%
Synonyms PF543,PF 543
SMILES CC1=CC(=CC(=C1)OCC2=CC=C(C=C2)CN3CCC[[email protected]@H]3CO)CS(=O)(=O)C4=CC=CC=C4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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