United States
You have no items in your shopping cart.
Publications citing Adooq Products
Chemical Information
| Catalog Num | A12451 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 367.3 |
| Formula | C16H18N2OS.HBr |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 63208-82-2 |
| Synonyms | N/A |
| SMILES code | CC1=CC=C(C=C1)C(=O)CN2C3=C(CCCC3)SC2=N.Br |
| Chemical Name | 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone hydrobromide |
Description |
Pifithrin-a is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression. | ||||||||||
Targets |
|
||||||||||
| Solubility (25°C) * | In vitro | DMSO | 67 mg/mL (182.41 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.23 mL | 136.13 mL | 272.26mL |
| 0.5 mM | 5.45 mL | 27.23 mL | 54.45 mL |
| 1 mM | 2.72 mL | 13.61 mL | 27.23 mL |
| 5 mM | 0.54 mL | 2.72 mL | 5.45 mL |
*The above data is based on the productmolecular weight 367.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|
Cat. No. | Product Name | Solubility(mg/mL) | ||
|---|---|---|---|---|
| Water | DMSO | Ethanol | ||
| A10255 | ABT-737 | <1 mg/mL | 163 mg/mL | <1 mg/mL |
| A10022 | ABT-263 (Navitoclax) | <1 mg/mL | 195 mg/mL | <1 mg/mL |
| A10665 | Obatoclax mesylate (GX15-070) | <1 mg/mL | 83 mg/mL | <1 mg/mL |
| A10955 | TW-37 | <1 mg/mL | 115 mg/mL | 4 mg/mL |
| A10984 | VX-765 | <1 mg/mL | 102 mg/mL | 102 mg/mL |
| A11090 | PAC-1 | <1 mg/mL | 78 mg/mL | 16 mg/mL |
| A10491 | JNJ 26854165 | <1 mg/mL | 66 mg/mL | 2 mg/mL |
| A11931 | RITA (NSC 652287) | <1 mg/mL | 115 mg/mL | 4 mg/mL |
| A10522 | Lenalidomide (CC-5013) | <1 mg/mL | 52 mg/mL | <1 mg/mL |
| A10743 | Pomalidomide (CC-4047) | <1 mg/mL | 55 mg/mL | <1 mg/mL |
| A11163 | AT-406 | <1 mg/mL | 112 mg/mL | 112 mg/mL |
| A11002 | YM155 | 89 mg/mL | 55 mg/mL | 6 mg/mL |
| A10935 | Tipifarnib (Zarnestra) | <1 mg/mL | 83 mg/mL | <1 mg/mL |
| A10657 | Nutlin-3 | <1 mg/mL | 116 mg/mL | 116 mg/mL |
Ordering online
To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.
To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.
When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards. We will then liaise with you or your purchasing department to confirm the order.
Found your products but not ready to order?
Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.
Ordering offline
You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order. Our contact details are:
- Tel: 866-930-6790
- Fax: 323-606-8156
- Email: [email protected]
We require the following information to process your order:
- The catalog number for each product.
- Your email address or fax number.
- Your name and telephone number.
- Shipping address and billing address.
- Purchase order numbers.
Similar product(s)
Special Price Starting at:
$45.00
JNJ-26854165 is one of p53-activating agents and synergizes with AraC or doxorubicin to induce p53-mediated apoptosis and may provide a novel therapeutic approach for the treatment of acute leukemias. ...
Special Price Starting at: $45.00
Special Price Starting at:
$65.00
WR 1065, a dephosphorylated metabolite of amifostine (Ethyol), can protect against the immediate and delayed effects of radiation exposure. ...
Special Price Starting at: $65.00
Special Price Starting at:
$280.00
N/A ...
Special Price Starting at: $280.00
Special Price Starting at:
$115.00
RETRA hydrochloride is an antitumor agent which inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and iin vivo. ...
Special Price Starting at: $115.00
Special Price Starting at:
$54.00
NSC 319726 is a potent and selective activator of mutant p53R175 ...
Special Price Starting at: $54.00
Special Price Starting at:
$105.00
NSC 146109 hydrochloride is a cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. ...
Special Price Starting at: $105.00
Special Price Starting at:
$45.00
Pifithrin-beta is a small molecule inhibitor of p53. ...
Special Price Starting at: $45.00
Special Price Starting at:
$220.00
p53 and MDM2 proteins-interaction-inhibitor racemic is an inhibitor of the interaction between p53 and MDM2 proteins. ...
Special Price Starting at: $220.00
Special Price Starting at:
$63.00
RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis. ...
Special Price Starting at: $63.00
Special Price Starting at:
$110.00
NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of ...
Special Price Starting at: $110.00
Special Price Starting at:
$90.00
Tenovin-6 is a analog of tenovin-1. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 uM, respectively. ...
Special Price Starting at: $90.00
Special Price Starting at:
$110.00
SJ 172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified. ...
Special Price Starting at: $110.00
Special Price Starting at:
$80.00
PRIMA-1 is a small molecule identified for its p53 reactivating effect. ...
Special Price Starting at: $80.00
Special Price Starting at:
$135.00
PhiKan 083, p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. ...
Special Price Starting at: $135.00
Special Price Starting at:
$50.00
inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. ...
Special Price Starting at: $50.00
Special Price Starting at:
$90.00
MIRA-1 restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA. ...
Special Price Starting at: $90.00
Special Price Starting at:
$71.00
Tenovin-1 is a small molecule activator of p53 transcriptional activity that protects against MDM2-mediated p53 degradation. ...
Special Price Starting at: $71.00
Special Price Starting at:
$120.00
RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2. ...
Special Price Starting at: $120.00
Special Price Starting at:
$580.00
p53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins. ...
Special Price Starting at: $580.00
Keywords:buy Pifithrin-alpha | Pifithrin-alpha Supplier | purchase Pifithrin-alpha | Pifithrin-alpha cost | Pifithrin-alpha manufacturer | order Pifithrin-alpha | Pifithrin-alpha distributor | buy 63208-82-2| 63208-82-2 Supplier | purchase 63208-82-2 | 63208-82-2 cost | 63208-82-2 manufacturer | order 63208-82-2 | 63208-82-2 distributor
We Using Safe Payments:
