Pifithrin-α hydrobromide is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression.
Pifithrin-α hydrobromide is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression.
Targets
Target
Value
Product Information
Catalog Num
A12451
Formula
C16H18N2OS.HBr
Molecular Weight
367.3
CAS Number
63208-82-2
SMILES
CC1=CC=C(C=C1)C(=O)CN2C3=C(CCCC3)SC2=N.Br
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Solubility
In vitro (25°C)
DMSO
58 mg/mL (157.91 mM)
Water
Insoluble
Ethanol
Insoluble
In vivo
5% DMSO+ 40% PEG 300+ 5%Tween80+ 50%ddH2O
3.46 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula: