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Pifithrin-alpha

Pifithrin-alpha

Name: Pifithrin-alpha
SKU: A12451

Catalog No.: A12451

p53 inhibitor

Pifithrin-alpha Chemical Structure

CAS NO. 63208-82-2

Pifithrin-a is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression.

Availability: In stock

Package	Price	Qty
5 mg	$50.00
10 mg	$85.00
25 mg	$200.00
50 mg	$290.00
10mM * 1mL in DMSO	$96.00

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Biological Activity

Pifithrin-a is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression.

Targets

p53

Solubility *

In vitro (25°C)	DMSO	67 mg/mL (182.41 mM)
	Water	<1 mg/mL (<1 mM)
	Ethanol	<1 mg/mL (<1 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	30 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.23 mL	136.13 mL	272.26 mL
0.5 mM	5.45 mL	27.23 mL	54.45 mL
1 mM	2.72 mL	13.61 mL	27.23 mL
5 mM	0.54 mL	2.72 mL	5.45 mL

*The above data is based on the productmolecular weight 367.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A12451
Actions	Inhibitor
M. Wt	367.3
Formula	C16H18N2OS.HBr
Solubility	DMSO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	63208-82-2
SMILES	CC1=CC=C(C=C1)C(=O)CN2C3=C(CCCC3)SC2=N.Br