Pifithrin-alpha

Name: Pifithrin-alpha
Brand: Adooq Bioscience
SKU: A12451
Rating: 100 (268 reviews)

Catalog No.: A12451

p53 inhibitor

Pifithrin-alpha Chemical Structure

CAS NO. 63208-82-2

Pifithrin-a is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression.

Availability: In stock

Package	Price	Qty
5 mg	$50.00
10 mg	$85.00
25 mg	$200.00
50 mg	$290.00
10mM * 1mL in DMSO	$96.00
Custom Size	Get quote

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Adooq Products cited in reputable paper

Biological Activity

Pifithrin-a is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression.

Targets

p53

Solubility *

In vitro (25°C)	DMSO	58 mg/mL (157.91 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+ 40% PEG 300+ 5%Tween80+ 50%ddH2O	3.46 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.23 mL	136.13 mL	272.26 mL
0.5 mM	5.45 mL	27.23 mL	54.45 mL
1 mM	2.72 mL	13.61 mL	27.23 mL
5 mM	0.54 mL	2.72 mL	5.45 mL

*The above data is based on the productmolecular weight 367.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A12451
Actions	Inhibitor
CAS No.	63208-82-2
Formula	C16H18N2OS.HBr
M. Wt	367.3
Purity	>98%
SMILES	CC1=CC=C(C=C1)C(=O)CN2C3=C(CCCC3)SC2=N.Br
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.