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Pifithrin-alpha

Pifithrin-alpha

Name: Pifithrin-alpha
SKU: A12451

Catalog No.: A12451

p53 inhibitor

Pifithrin-alpha

Pifithrin-alpha Chemical Structure

CAS NO. 63208-82-2

Pifithrin-a is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression.

Availability: In stock

Package	Price	Qty
5 mg	Regular Price: $50.00 Special Price $40.00
10 mg	Regular Price: $85.00 Special Price $68.00
25 mg	Regular Price: $200.00 Special Price $160.00
50 mg	Regular Price: $350.00 Special Price $280.00
10mM * 1mL in DMSO	$96.00

Price Match Request

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable papers

Nature 2017
551, 247-250

Science
2017; 356(6336)

Nat Chem Biol.
1, 713–720 (2015)

Nat Commun
2016; 7: 11051.

Nat Cell Biol. 2013
15(12):1473-85.

Cell 2014 Feb 27
156(5):986-1001.

Nat Commun
2015; 6: 7139.

PNAS 2014
111(43) 15514-15519

PNAS 2014
111(23) E2404-E2413

J Neurosci. 2015
35(5): 2101–2111

Scientific Reports
5, 12298.

Cell Research
225, 707–725.

Oncogene
2014, 1–14 .

Details

Biological Activity

Pifithrin-a is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression.

Targets

p53

Solubility *

In vitro (25°C)	DMSO	67 mg/mL (182.41 mM)
	Water	<1 mg/mL (<1 mM)
	Ethanol	<1 mg/mL (<1 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	30 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.23 mL	136.13 mL	272.26 mL
0.5 mM	5.45 mL	27.23 mL	54.45 mL
1 mM	2.72 mL	13.61 mL	27.23 mL
5 mM	0.54 mL	2.72 mL	5.45 mL

*The above data is based on the productmolecular weight 367.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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p53

Technical Details

Catalog Num	A12451
Actions	Inhibitor
M. Wt	367.3
Formula	C16H18N2OS.HBr
Solubility	DMSO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	63208-82-2
Synonyms	N/A
SMILES	CC1=CC=C(C=C1)C(=O)CN2C3=C(CCCC3)SC2=N.Br