Pifithrin-alpha

Catalog No.: A12451

p53 inhibitor

Pifithrin-alpha

Pifithrin-alpha Chemical Structure

CAS NO. 63208-82-2

Pifithrin-a is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression.

Availability: In stock

Package Price Qty
5 mg
$50.00
10 mg
$85.00
25 mg
$200.00
50 mg
$290.00
10mM * 1mL in DMSO
$96.00
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Biological Activity

Pifithrin-a is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression.
Targets
p53
In vitro (25°C) DMSO 58 mg/mL (157.91 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+ 40% PEG 300+ 5%Tween80+ 50%ddH2O 3.46 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.23 mL 136.13 mL 272.26 mL
0.5 mM 5.45 mL 27.23 mL 54.45 mL
1 mM 2.72 mL 13.61 mL 27.23 mL
5 mM 0.54 mL 2.72 mL 5.45 mL

*The above data is based on the productmolecular weight 367.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12451
Actions Inhibitor
CAS No. 63208-82-2
Formula C16H18N2OS.HBr
M. Wt 367.3
Purity >98%
SMILES CC1=CC=C(C=C1)C(=O)CN2C3=C(CCCC3)SC2=N.Br
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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