PLX5622

Name: PLX5622
Brand: Adooq Bioscience
SKU: A18888
Rating: 5 (2 reviews)

Catalog No.: A18888

CSF1R inhibitor

Adooq's PLX5622 has been cited by 2 publications

PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor with an Ki of 5.9 nM, for extended and specific microglial elimination, preceding and during pathology development.

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Grouped product items
Size	Price	Stock
2mg	$45.00	In stock
5mg	$90.00	In stock
10mg	$155.00	In stock
25mg	$315.00	In stock
50mg	$530.00	In stock
100mg	$640.00	In stock
500mg	$1,375.00	In stock
*10mM 1mL in DMSO**	$80.00	In stock
Bulk Size	Bulk Discount

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Adooq Products cited in reputable paper

Adooq's PLX5622 has been cited by 2 publications

Sang Hwan Lee, .et al. , Brain, 2024, Aug 28:awae221 PMID: 39194073
Ilija Brizic, .et al. , Research Square, 2024, October 3rd

Biological Activity

Description	PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor with an Ki of 5.9 nM, for extended and specific microglial elimination, preceding and during pathology development.

Product Information

Catalog Num	A18888
Formula	C21H19F2N5O
Molecular Weight	395.41
CAS Number	1303420-67-8
SMILES	COC1=NC=C(F)C=C1CNC2=NC(F)=C(CC3=CNC4=NC=C(C)C=C43)C=C2
Synonyms	PLX 5622, PLX-5622
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro	DMSO	71 mg/mL (179.56 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.29 mL	126.45 mL	252.9 mL
0.5 mM	5.06 mL	25.29 mL	50.58 mL
1 mM	2.53 mL	12.65 mL	25.29 mL
5 mM	0.51 mL	2.53 mL	5.06 mL

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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂