PLX5622

Catalog No.: A18888

CSF1R inhibitor

PLX5622

PLX5622 Chemical Structure

CAS NO. 1303420-67-8

PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor with an Ki of 5.9 nM, for extended and specific microglial elimination, preceding and during pathology development.

Availability: In stock

Package Price Qty
2 mg
$50.00
5 mg
$100.00
10 mg
$170.00
50 mg
$580.00
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Biological Activity

PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor with an Ki of 5.9 nM, for extended and specific microglial elimination, preceding and during pathology development.
In vitro DMSO 71 mg/mL (179.56 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.29 mL 126.45 mL 252.9 mL
0.5 mM 5.06 mL 25.29 mL 50.58 mL
1 mM 2.53 mL 12.65 mL 25.29 mL
5 mM 0.51 mL 2.53 mL 5.06 mL

*The above data is based on the productmolecular weight 395.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18888
Actions Inhibitor
CAS No. 1303420-67-8
Formula C21H19F2N5O
M. Wt 395.41
Solubility DMSO
Purity >98%
Synonyms PLX 5622, PLX-5622
SMILES COC1=NC=C(F)C=C1CNC2=NC(F)=C(CC3=CNC4=NC=C(C)C=C43)C=C2
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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