Poseltinib (HM71224, LY3337641)

Catalog No.: A19450

BTK inhibitor

Poseltinib (HM71224, LY3337641)

Poseltinib (HM71224, LY3337641) Chemical Structure

CAS NO. 1353552-97-2

Poseltinib, an orally active, selective and irreversible Bruton??s tyrosine kinase (BTK) inhibitor (IC50 =1.95 nM), with 0.3, 2.3 and 2.4-fold selectivity for BTK over BMX, TEC and TXK, respectively.

Availability: In stock

Package Price Qty
1 mg
$320.00
5 mg
$960.00
10 mg
$1,600.00
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Biological Activity

Poseltinib, an orally active, selective and irreversible Bruton??s tyrosine kinase (BTK) inhibitor (IC50 =1.95 nM), with 0.3, 2.3 and 2.4-fold selectivity for BTK over BMX, TEC and TXK, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.25 mL 106.27 mL 212.53 mL
0.5 mM 4.25 mL 21.25 mL 42.51 mL
1 mM 2.13 mL 10.63 mL 21.25 mL
5 mM 0.43 mL 2.13 mL 4.25 mL

*The above data is based on the productmolecular weight 470.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A19450
Actions Inhibitor
CAS No. 1353552-97-2
Formula C26H26N6O3
M. Wt 470.52
Purity >98%
Synonyms HM 71224, HM-71224, LY-333764, LY 33376411
SMILES O=C(C=C)NC1=CC=CC(OC2=C(OC=C3)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=N2)=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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