PP2

Catalog No.: A12723

Src Inhibitor

PP2 Chemical Structure

CAS NO. 172889-27-9

PP2 is a selective inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC50 = 0.73 μM).

Availability: In stock

Package Price Qty
10 mg
$100.00
25 mg
$220.00
50 mg
$300.00
100 mg
$500.00
10mM * 1mL in DMSO
$90.00

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Biological Activity

PP2 is a selective inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC50 = 0.73 μM).
Targets
LCK (Cell-free assay) Fyn (Cell-free assay) EGFR (Cell-free assay) JAK2 (Cell-free assay) ZAP70 (Cell-free assay)
4 nM5 nM480 nM>50 μM>100 μM
In vitro (25°C) DMSO 60 mg/mL (198.82 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (6.62 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.18 mL 160.89 mL 321.77 mL
0.5 mM 6.44 mL 32.18 mL 64.35 mL
1 mM 3.22 mL 16.09 mL 32.18 mL
5 mM 0.64 mL 3.22 mL 6.44 mL

*The above data is based on the productmolecular weight 310.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12723
Actions Inhibitor
M. Wt 310.78
Formula C15H16ClN5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 172889-27-9
Synonyms PP-2, PP 2
SMILES CC(C)(C)N1C2=C(C(=N1)C3=CC=C(C=C3)Cl)C(=NC=N2)N

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