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Biological Activity
PP2 is a selective inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC50 = 0.73 μM).
Targets
| LCK (Cell-free assay) | Fyn (Cell-free assay) | EGFR (Cell-free assay) | JAK2 (Cell-free assay) | ZAP70 (Cell-free assay) |
| 4 nM | 5 nM | 480 nM | >50 μM | >100 μM |
| In vitro (25°C) | DMSO | 52 mg/mL (172.31 mM) | |
| Water | Insoluble | ||
| Ethanol | 2 mg/mL (6.62 mM) | ||
| In vivo | 4% DMSO+corn oil | 2.3 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 33.14 mL | 165.68 mL | 331.37 mL |
| 0.5 mM | 6.63 mL | 33.14 mL | 66.27 mL |
| 1 mM | 3.31 mL | 16.57 mL | 33.14 mL |
| 5 mM | 0.66 mL | 3.31 mL | 6.63 mL |
*The above data is based on the productmolecular weight 301.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12723 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 172889-27-9 |
| Formula | C15H16ClN5 |
| M. Wt | 301.78 |
| Purity | >98% |
| Synonyms | PP-2, PP 2 |
| SMILES | CC(C)(C)N1C2=C(C(=N1)C3=CC=C(C=C3)Cl)C(=NC=N2)N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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