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PROTAC ALK degrader-1

Catalog No.: A34539
ALK Degrader
PROTAC ALK degrader-1 is a potent ALK degrader utilizing the proteolysis-targeting chimera (PROTAC) mechanism, exhibiting a DC50 of 26 nM in H3122 EML4-ALK cells. This compound enables selective degradation of ALK, thereby offering potential therapeutic benefits for ALK-driven cancers. Additionally, PROTAC ALK degrader-1 serves as a precursor for synthesizing PROTAC ALK degrader-2, which may possess enhanced bioavailability for further research applications.
PROTAC ALK degrader-1 3049802-45-8 ALK Degrader
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPROTAC ALK degrader-1 is a potent ALK degrader utilizing the proteolysis-targeting chimera (PROTAC) mechanism, exhibiting a DC50 of 26 nM in H3122 EML4-ALK cells. This compound enables selective degradation of ALK, thereby offering potential therapeutic benefits for ALK-driven cancers. Additionally, PROTAC ALK degrader-1 serves as a precursor for synthesizing PROTAC ALK degrader-2, which may possess enhanced bioavailability for further research applications.
Product Information
Catalog NumA34539
FormulaC47H55ClN10O9S
Molecular Weight971.52
CAS Number3049802-45-8
SMILESCC(C)S(C1=C(NC2=C(Cl)C=NC(NC3=C(OC(C)C)C=C(C4CCN(CC(NCC(NCCNC5=CC=CC(C(N6C7CCC(NC7=O)=O)=O)=C5C6=O)=O)=O)CC4)C(C)=C3)=N2)C=CC=C1)(=O)=O
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This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Protein Tyrosine Kinases > ALK
Angiogenesis > ALK