PROTAC IRAK4 ligand-4

Catalog No.: A64925
Ligand for Target Protein for PROTAC
PROTAC IRAK4 ligand-4 is a selective ligand that targets IRAK4, facilitating the degradation of this protein via the PROTAC (proteolysis-targeting chimera) mechanism. This compound exhibits antitumor activity, making it a valuable tool for cancer research. Additionally, it can be utilized to synthesize the PROTAC IRAK4 degrader-12, contributing to the development of targeted therapeutic strategies in oncology.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPROTAC IRAK4 ligand-4 is a selective ligand that targets IRAK4, facilitating the degradation of this protein via the PROTAC (proteolysis-targeting chimera) mechanism. This compound exhibits antitumor activity, making it a valuable tool for cancer research. Additionally, it can be utilized to synthesize the PROTAC IRAK4 degrader-12, contributing to the development of targeted therapeutic strategies in oncology.
Product Information
Catalog NumA64925
FormulaC24H26F2N6O3
Molecular Weight484.50
CAS Number2434841-55-9
SMILESO=C(C1=COC(C2=CC=NC(NCC3CC3)=C2)=N1)NC4=CN([C@H]5CC[C@@H](CC5)C=O)N=C4C(F)F
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