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PSMA-Val-Cit-PAB-MMAE

Catalog No.: A41399
Drug-Linker Conjugates for ADC Inhibitor
PSMA-Val-Cit-PAB-MMAE is a targeted drug-linker conjugate that utilizes monomethyl auristatin E (MMAE) to selectively inhibit prostate-specific membrane antigen (PSMA). This compound demonstrates potent cytotoxicity against PSMA-expressing tumor cells, making it a valuable tool for developing antibody-drug conjugates (ADCs) in prostate cancer therapy. Its design enhances the therapeutic efficacy while minimizing off-target effects in cancer treatment research.
PSMA-Val-Cit-PAB-MMAE 2748039-79-2 Drug-Linker Conjugates for ADC Inhibitor
Grouped product items
Size Price Stock Qty
1mg
$560.00
In stock
5mg
$1,460.00
In stock
10mg
$2,395.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPSMA-Val-Cit-PAB-MMAE is a targeted drug-linker conjugate that utilizes monomethyl auristatin E (MMAE) to selectively inhibit prostate-specific membrane antigen (PSMA). This compound demonstrates potent cytotoxicity against PSMA-expressing tumor cells, making it a valuable tool for developing antibody-drug conjugates (ADCs) in prostate cancer therapy. Its design enhances the therapeutic efficacy while minimizing off-target effects in cancer treatment research.
Product Information
Catalog NumA41399
FormulaC114H165ClN20O26
Molecular Weight2267.10
CAS Number2748039-79-2
SMILESOC(CC[C@@H](C(O)=O)NC(N[C@@H](CCCCN(CC1=CC(Cl)=CC=C1)C(CCCCCNC(CCC(N[C@H](C(N[C@H](C(NCCCN2N=NC(CCCC(N[C@H](C(N[C@H](C(NC3=CC=C(C=C3)COC(N([C@H](C(N[C@@H](C(C)C)C(N([C@H]([C@@H](CC(N4CCC[C@]4([C@@H]([C@@H](C)C(N[C@@H]([C@H](C5=CC=CC=C5)O)C)=O)OC)[H])=O)OC)[C@@H](C)CC)C)=O)=O)C(C)C)C)=O)=O)CCCNC(N)=O)=O)C(C)C)=O)=C2)=O)CC6=CC=C(C=C6)O)=O)CC7=CC=CC=C7)=O)=O)=O)C(O)=O)=O)=O
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC