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Py-MAA-Val-Cit-PAB-MMAE

Catalog No.: A41360
Drug-Linker Conjugates for ADC
Py-MAA-Val-Cit-PAB-MMAE is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, featuring the potent cytotoxic agent MMAE. This compound facilitates the synthesis of Zapadcine-3a, which selectively targets TRAILR2. Zapadcine-3a exhibits broad-spectrum anti-tumor activity, effectively inducing apoptosis in TRAILR2-positive tumors. This makes Py-MAA-Val-Cit-PAB-MMAE a valuable tool for advancing targeted cancer therapeutics.
Py-MAA-Val-Cit-PAB-MMAE 2247398-68-9 Drug-Linker Conjugates for ADC
Grouped product items
Size Price Stock Qty
5mg
$335.00
In stock
10mg
$550.00
In stock
25mg
$1,110.00
In stock
50mg
$1,740.00
In stock
100mg
$2,720.00
In stock
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Free Delivery on orders over $500
Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPy-MAA-Val-Cit-PAB-MMAE is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, featuring the potent cytotoxic agent MMAE. This compound facilitates the synthesis of Zapadcine-3a, which selectively targets TRAILR2. Zapadcine-3a exhibits broad-spectrum anti-tumor activity, effectively inducing apoptosis in TRAILR2-positive tumors. This makes Py-MAA-Val-Cit-PAB-MMAE a valuable tool for advancing targeted cancer therapeutics.
Product Information
Catalog NumA41360
FormulaC72H111N13O16S
Molecular Weight1446.79
CAS Number2247398-68-9
SMILESO[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CSCCC(N4CN(CN(C4)C(C=C)=O)C(C=C)=O)=O)=O)=O)=O)=O)=O)=O)=O)OC)=O
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC