RET/TRKA-IN-1 is a dual inhibitor targeting both RET and TRKA, with an IC50 value of 0.375 µM for RET. This reagent has demonstrated significant anti-proliferative effects on LC-2 and KM12 cell lines, exhibiting GI50 values of 0.72 µM and 0.25 µM, respectively. Additionally, RET/TRKA-IN-1 effectively induces cell cycle arrest at the G1 phase, making it a valuable tool for research on cancer biology and therapeutic development.
RET/TRKA-IN-1 is a dual inhibitor targeting both RET and TRKA, with an IC50 value of 0.375 µM for RET. This reagent has demonstrated significant anti-proliferative effects on LC-2 and KM12 cell lines, exhibiting GI50 values of 0.72 µM and 0.25 µM, respectively. Additionally, RET/TRKA-IN-1 effectively induces cell cycle arrest at the G1 phase, making it a valuable tool for research on cancer biology and therapeutic development.
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