RIPK1-IN-39 is a selective inhibitor of receptor-interacting protein kinase 1 (RIPK1), exhibiting an IC50 value of 69.40 nM and more than 100-fold selectivity over RIPK3 (IC50 = 6946 nM). This compound effectively prevents necroptosis in HT-22 and HT-29 cell lines by inhibiting the phosphorylation and activation of the RIPK1-RIPK3-MLKL signaling pathway. Additionally, RIPK1-IN-39 has demonstrated neuroprotective effects in a rat model of middle cerebral artery occlusion (MCAO), making it a valuable tool for research in acute ischemic stroke (AIS).
RIPK1-IN-39 is a selective inhibitor of receptor-interacting protein kinase 1 (RIPK1), exhibiting an IC50 value of 69.40 nM and more than 100-fold selectivity over RIPK3 (IC50 = 6946 nM). This compound effectively prevents necroptosis in HT-22 and HT-29 cell lines by inhibiting the phosphorylation and activation of the RIPK1-RIPK3-MLKL signaling pathway. Additionally, RIPK1-IN-39 has demonstrated neuroprotective effects in a rat model of middle cerebral artery occlusion (MCAO), making it a valuable tool for research in acute ischemic stroke (AIS).
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