Catalog No.: A12535

BTK inhibitor


RN486 Chemical Structure

CAS NO. 1242156-23-5

RN486 is a Bruton's tyrosine kinase (Btk) inhibitor.

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Biological Activity

RN486 is a Bruton's tyrosine kinase (Btk) inhibitor.
4 nM
In vitro (25°C) DMSO Warmed: 61 mg/mL (100.54 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+30% PEG 300+10% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.48 mL 82.41 mL 164.83 mL
0.5 mM 3.3 mL 16.48 mL 32.97 mL
1 mM 1.65 mL 8.24 mL 16.48 mL
5 mM 0.33 mL 1.65 mL 3.3 mL

*The above data is based on the productmolecular weight 606.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12535
Actions Inhibitor
CAS No. 1242156-23-5
Formula C35H35FN6O3
M. Wt 606.7
Purity >98%
Synonyms RN-486,RN 486

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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