Runimotamab is a chimeric humanized antibody of the IgG1-κ isotype, designed to specifically target CD3E and HER2 receptors. This dual targeting strategy enhances the antibody's ability to mediate immune responses against cells expressing HER2, a receptor tyrosine kinase implicated in the progression of several forms of cancer, including breast and gastric cancers. Runimotamab's engagement of CD3E on T cells potentially facilitates a more direct and potent cytotoxic response, making it a valuable tool for research in cancer immunotherapy and the study of bispecific antibody mechanisms.
Runimotamab is a chimeric humanized antibody of the IgG1-κ isotype, designed to specifically target CD3E and HER2 receptors. This dual targeting strategy enhances the antibody's ability to mediate immune responses against cells expressing HER2, a receptor tyrosine kinase implicated in the progression of several forms of cancer, including breast and gastric cancers. Runimotamab's engagement of CD3E on T cells potentially facilitates a more direct and potent cytotoxic response, making it a valuable tool for research in cancer immunotherapy and the study of bispecific antibody mechanisms.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
Frequently Asked Questions
What are Biosimilar Antibodies?
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research.
Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
