Sabutoclax

Catalog No.: A12823

Bcl-2 inhibitor

Sabutoclax

Sabutoclax Chemical Structure

CAS NO. 1228108-65-3

Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.

Availability: In stock

Package Price Qty
5 mg
$145.00
10 mg
$250.00
25 mg
$320.00
50 mg
$675.00
10mM * 1mL in DMSO
$409.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Christopher D. Graham, .et al. BH3 mimetics suppress CXCL12 expression in human malignant peripheral nerve sheath tumor cells, Oncotarget, 2017, Jan 31; 8(5): 8670-8678 PMID: 28055968

Biological Activity

Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.
Targets
Mcl-1 Bcl-xL Bcl-2 Bfl-1
0.20 μM0.31 μM0.32 μM0.62 μM
In vitro DMSO Warmed: 93 mg/mL (132.7 mM)
Water Insoluble
Ethanol Warmed: 50 mg/mL (71.34 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.27 mL 71.35 mL 142.7 mL
0.5 mM 2.85 mL 14.27 mL 28.54 mL
1 mM 1.43 mL 7.13 mL 14.27 mL
5 mM 0.29 mL 1.43 mL 2.85 mL

*The above data is based on the productmolecular weight 700.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12823
Actions Inhibitor
CAS No. 1228108-65-3
Formula C42H40N2O8
M. Wt 700.78
Purity >98%
Synonyms BI-97C1,BI97C1
SMILES CC1=C(C(=C2C=C(C(=C(C2=C1)C(=O)NC[[email protected]](C)C3=CC=CC=C3)O)O)O)C4=C(C=C5C(=C4O)C=C(C(=C5C(=O)NC[[email protected]](C)C6=CC=CC=C6)O)O)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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