Sabutoclax

Catalog No.: A12823

Bcl-2 inhibitor

Sabutoclax Chemical Structure

CAS NO. 1228108-65-3

Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.

Availability: In stock

Package Price Qty
5 mg
$145.00
10 mg
$250.00
25 mg
$320.00
50 mg
$675.00
10mM * 1mL in DMSO
$409.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.
Targets
Mcl-1 Bcl-xL Bcl-2 Bfl-1
0.20 μM0.31 μM0.32 μM0.62 μM
In vitro DMSO 100 mg/mL heating (142.69 mM)
Water <1 mg/mL (<1 mM)
Ethanol 54 mg/mL heating (77.05 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.27 mL 71.35 mL 142.7 mL
0.5 mM 2.85 mL 14.27 mL 28.54 mL
1 mM 1.43 mL 7.13 mL 14.27 mL
5 mM 0.29 mL 1.43 mL 2.85 mL

*The above data is based on the productmolecular weight 700.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12823
Actions Inhibitor
M. Wt 700.78
Formula C42H40N2O8
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1228108-65-3
Synonyms BI-97C1,BI97C1
SMILES CC1=C(C(=C2C=C(C(=C(C2=C1)C(=O)NC[[email protected]](C)C3=CC=CC=C3)O)O)O)C4=C(C=C5C(=C4O)C=C(C(=C5C(=O)NC[[email protected]](C)C6=CC=CC=C6)O)O)C

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