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Bcl-2 inhibitor

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Catalog No. A12823

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Sabutoclax 5mg A12823-5
Sabutoclax 10mg A12823-10
Sabutoclax 25mg A12823-25
Sabutoclax 50mg A12823-50
Sabutoclax 10mM * 1mL in DMSO A12823-10mM-D

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.


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Publications citing Adooq Products
Sabutoclax Citations (1)
  • Christopher D. Graham, .et al. BH3 mimetics suppress CXCL12 expression in human malignant peripheral nerve sheath tumor cells, Oncotarget, 2017, Jan 31; 8(5): 8670-8678 PMID: 28055968

Chemical Information

Catalog Num A12823
Actions Inhibitor
M. Wt 700.78
Formula C42H40N2O8
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1228108-65-3
Synonyms BI-97C1,BI97C1
SMILES CC1=C(C(=C2C=C(C(=C(C2=C1)C(=O)NC[[email protected]](C)C3=CC=CC=C3)O)O)O)C4=C(C=C5C(=C4O)C=C(C(=C5C(=O)NC[[email protected]](C)C6=CC=CC=C6)O)O)C

Biological Activity

Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.
Mcl-1 Bcl-xL Bcl-2 Bfl-1
0.20 μM0.31 μM0.32 μM0.62 μM


Solubility (25°C)* In vitro DMSO 100 mg/mL heating (142.69 mM)
Water <1 mg/mL (<1 mM)
Ethanol 54 mg/mL heating (77.05 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.27 mL 71.35 mL 142.7mL
0.5 mM 2.85 mL 14.27 mL 28.54 mL
1 mM 1.43 mL 7.13 mL 14.27 mL
5 mM 0.29 mL 1.43 mL 2.85 mL

*The above data is based on the productmolecular weight 700.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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