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$0.00 - Christopher D. Graham, .et al. BH3 mimetics suppress CXCL12 expression in human malignant peripheral nerve sheath tumor cells, Oncotarget, 2017, Jan 31; 8(5): 8670-8678 PMID: 28055968
Biological Activity
Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.
Targets
| Mcl-1 | Bcl-xL | Bcl-2 | Bfl-1 | |
| 0.20 μM | 0.31 μM | 0.32 μM | 0.62 μM |
| In vitro | DMSO | Warmed: 93 mg/mL (132.7 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 50 mg/mL (71.34 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 14.27 mL | 71.35 mL | 142.7 mL |
| 0.5 mM | 2.85 mL | 14.27 mL | 28.54 mL |
| 1 mM | 1.43 mL | 7.13 mL | 14.27 mL |
| 5 mM | 0.29 mL | 1.43 mL | 2.85 mL |
*The above data is based on the productmolecular weight 700.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12823 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1228108-65-3 |
| Formula | C42H40N2O8 |
| M. Wt | 700.78 |
| Purity | >98% |
| Synonyms | BI-97C1,BI97C1 |
| SMILES | CC1=C(C(=C2C=C(C(=C(C2=C1)C(=O)NC[[email protected]](C)C3=CC=CC=C3)O)O)O)C4=C(C=C5C(=C4O)C=C(C(=C5C(=O)NC[[email protected]](C)C6=CC=CC=C6)O)O)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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