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Saracatinib (AZD0530)

Catalog No.: A10108

Src/Abl inhibitor

Saracatinib (AZD0530)

Saracatinib (AZD0530) Chemical Structure

CAS NO. 379231-04-6

Saracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively.

Availability: In stock

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10 mg
25 mg
100 mg
200 mg
10mM * 1mL in DMSO
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  • Andromachi Lambrianidou, .et al. mTORC2 deploys the mRNA binding protein IGF2BP1 to regulate c-MYC expression and promote cell survival, Cell Signal, 2021, Apr;80:109912 PMID: 33388443
  • Chisato Naito, .et al. Facilitatory effects of fetuin-A on atherosclerosis, Atherosclerosis, 2016, Mar;246:344-51 PMID: 26828753
  • Kenta Maruyama, .et al. 5-Azacytidine-induced Protein 2 (AZI2) Regulates Bone Mass by Fine-tuning Osteoclast Survival, J Biol Chem, 2015, Apr 10; 290(15): 9377-9386 PMID: 25691576
  • Amanda L Jackson, .et al. Emerging therapies: angiogenesis inhibitors for ovarian cancer, Expert Opin Emerg Drugs, 2015, Jun;20(2):331-46 PMID: 26001052

Biological Activity

Saracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively.
Target Value
c-SrcIC50: 2.7nM
LCKIC50: <4nM
c-YESIC50: 4nM
EGFR(L861Q)IC50: 4nM
LynIC50: 5nM
EGFR(L858R)IC50: 5nM
FynIC50: 10nM
FGRIC50: 10nM
BLKIC50: 11nM
v-AblIC50: 30nM
EGFRIC50: 66nM
c-KitIC50: 200nM
EphA2IC50: 236nM
CSKIC50: >1μM
PDGFRβIC50: >5μM
PDGFRαIC50: 10μM
CDK2IC50: 10μM
VEGFR3/FLT4IC50: >10μM
FGFR1IC50: >10μM
MEKIC50: 14μM
VEGFR1/FLT1IC50: >100μM
In vitro (25°C) DMSO Warmed: 34 mg/mL (62.73 mM)
Water Insoluble
Ethanol 30 mg/mL (55.35 mM)
In vivo 2% DMSO+30% PEG 300+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.45 mL 92.25 mL 184.5 mL
0.5 mM 3.69 mL 18.45 mL 36.9 mL
1 mM 1.85 mL 9.23 mL 18.45 mL
5 mM 0.37 mL 1.85 mL 3.69 mL

*The above data is based on the productmolecular weight 542.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10108
Actions Inhibitor
CAS No. 379231-04-6
Formula C27H32ClN5O5
M. Wt 542.0
Purity >98%
Synonyms AZD-0530

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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