Saracatinib (AZD0530)

Catalog No.: A10108

Src/Abl inhibitor

Saracatinib (AZD0530) Chemical Structure

CAS NO. 379231-04-6

Saracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively.

Availability: In stock

Package Price Qty
10 mg
$60.00
25 mg
$90.00
100 mg
$220.00
200 mg
$390.00
10mM * 1mL in DMSO
$92.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Saracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively.
Targets
Target Value
c-SrcIC50: 2.7nM
LCKIC50: <4nM
c-YESIC50: 4nM
EGFR(L861Q)IC50: 4nM
LynIC50: 5nM
EGFR(L858R)IC50: 5nM
FynIC50: 10nM
FGRIC50: 10nM
BLKIC50: 11nM
v-AblIC50: 30nM
EGFRIC50: 66nM
c-KitIC50: 200nM
EphA2IC50: 236nM
CSKIC50: >1μM
PDGFRβIC50: >5μM
PDGFRαIC50: 10μM
CDK2IC50: 10μM
VEGFR3/FLT4IC50: >10μM
FGFR1IC50: >10μM
MEKIC50: 14μM
VEGFR2/KDRIC50: 21μM
VEGFR1/FLT1IC50: >100μM
In vitro (25°C) DMSO 100 mg/mL (184.49 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (184.49 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.45 mL 92.25 mL 184.5 mL
0.5 mM 3.69 mL 18.45 mL 36.9 mL
1 mM 1.85 mL 9.23 mL 18.45 mL
5 mM 0.37 mL 1.85 mL 3.69 mL

*The above data is based on the productmolecular weight 542.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10108
Actions Inhibitor
M. Wt 542.0
Formula C27H32ClN5O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 379231-04-6
Synonyms AZD-0530
SMILES CN1CCN(CC1)CCOC2=CC(=C3C(=C2)N=CN=C3NC4=C(C=CC5=C4OCO5)Cl)OC6CCOCC6

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