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SC-VC-PAB-MMAE

Catalog No.: A41350
Drug-Linker Conjugate for ADC
SC-VC-PAB-MMAE is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This molecule features the potent antitumor agent monomethyl auristatin E (MMAE), a tubulin inhibitor that disrupts microtubule dynamics, linked through a cleavable SC-VC-PAB linker. SC-VC-PAB-MMAE demonstrates effective cytotoxicity in targeted cancer therapies, making it a valuable tool for research in oncology and ADC development.
SC-VC-PAB-MMAE 2259318-46-0 Drug-Linker Conjugate for ADC
Grouped product items
Size Price Stock Qty
1mg
$280.00
In stock
5mg
$860.00
In stock
10mg
$1,260.00
In stock
50mg
$3,075.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSC-VC-PAB-MMAE is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This molecule features the potent antitumor agent monomethyl auristatin E (MMAE), a tubulin inhibitor that disrupts microtubule dynamics, linked through a cleavable SC-VC-PAB linker. SC-VC-PAB-MMAE demonstrates effective cytotoxicity in targeted cancer therapies, making it a valuable tool for research in oncology and ADC development.
Product Information
Catalog NumA41350
FormulaC68H105N11O17
Molecular Weight1348.62
CAS Number2259318-46-0
SMILESO=C([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCC(ON1C(CCC1=O)=O)=O)=O)=O)NC(C=C2)=CC=C2COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N3[C@H]([C@H](OC)[C@@H](C)C(N[C@@H]([C@@H](O)C4=CC=CC=C4)C)=O)CCC3)=O)=O)=O)=O
SynonymsNHS-VC-PAB-MMAE
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC