Selonsertib

Catalog No.: A15991

ASK1 inhibitor

Selonsertib

Selonsertib Chemical Structure

CAS NO. 1448428-04-3

Selonsertib is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.

Availability: In stock

Package Price Qty
5 mg
$60.00
10 mg
$110.00
50 mg
$320.00
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  • Luwa Yuan, .et al. 14-3-3 signal adaptor and scaffold proteins mediate GPCR trafficking, Sci Rep, 2019, 9:11156 PMID: 31371790

Biological Activity

Selonsertib is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.
Targets
ASK1
In vitro DMSO 34 mg/mL (76.31 mM)
Water Insoluble
Ethanol 23 mg/mL (51.63 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.45 mL 112.23 mL 224.47 mL
0.5 mM 4.49 mL 22.45 mL 44.89 mL
1 mM 2.24 mL 11.22 mL 22.45 mL
5 mM 0.45 mL 2.24 mL 4.49 mL

*The above data is based on the productmolecular weight 445.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15991
Actions Inhibitor
CAS No. 1448428-04-3
Formula C24H24FN7O
M. Wt 445.5
Purity >98%
Synonyms GS-4997, GS4997, GS 4997
SMILES O=C(NC1=NC(C2=NN=CN2C(C)C)=CC=C1)C3=CC(N4C=C(C5CC5)N=C4)=C(C)C=C3F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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