- Luwa Yuan, .et al. 14-3-3 signal adaptor and scaffold proteins mediate GPCR trafficking, Sci Rep, 2019, 9:11156 PMID: 31371790
Biological Activity
Selonsertib is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.
Targets
ASK1 | ||||
In vitro | DMSO | 34 mg/mL (76.31 mM) | |
Water | Insoluble | ||
Ethanol | 23 mg/mL (51.63 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 22.45 mL | 112.23 mL | 224.47 mL |
0.5 mM | 4.49 mL | 22.45 mL | 44.89 mL |
1 mM | 2.24 mL | 11.22 mL | 22.45 mL |
5 mM | 0.45 mL | 2.24 mL | 4.49 mL |
*The above data is based on the productmolecular weight 445.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A15991 |
---|---|
Actions | Inhibitor |
CAS No. | 1448428-04-3 |
Formula | C24H24FN7O |
M. Wt | 445.5 |
Purity | >98% |
Synonyms | GS-4997, GS4997, GS 4997 |
SMILES | O=C(NC1=NC(C2=NN=CN2C(C)C)=CC=C1)C3=CC(N4C=C(C5CC5)N=C4)=C(C)C=C3F |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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