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Sennoside B

Catalog No.: A12120
PDGFR Inhibitor
Sennoside B is a potent inhibitor of platelet-derived growth factor receptor (PDGFR). It effectively suppresses cell proliferation and reduces the phosphorylation of PDGFR-β, STAT-5, AKT, and ERK in response to PDGF-BB stimulation. Additionally, Sennoside B exhibits gastroprotective properties and is suitable for research applications focused on gastritis and related gastrointestinal disorders.
Sennoside B 128-57-4 PDGFR Inhibitor
Grouped product items
Size Price Stock Qty
10mg
$20.00
In stock
25mg
$40.00
In stock
50mg
$65.00
In stock
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Free Delivery on orders over $500
Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSennoside B is a potent inhibitor of platelet-derived growth factor receptor (PDGFR). It effectively suppresses cell proliferation and reduces the phosphorylation of PDGFR-β, STAT-5, AKT, and ERK in response to PDGF-BB stimulation. Additionally, Sennoside B exhibits gastroprotective properties and is suitable for research applications focused on gastritis and related gastrointestinal disorders.
Product Information
Catalog NumA12120
FormulaC42H38O20
Molecular Weight862.74
CAS Number128-57-4
SMILESO[C@@H]1[C@@H](O)[C@H](OC2=C(C(C(C(O)=CC(C(O)=O)=C3)=C3[C@]4([C@@]5(C(C=CC=C6O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)=C6C(C8=C5C=C(C(O)=O)C=C8O)=O)[H])[H])=O)C4=CC=C2)O[C@H](CO)[C@H]1O
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Protein Tyrosine Kinases > PDGFR
Angiogenesis > PDGFR