SGX-523

Catalog No.: A10839

c-Met Inhibitor

SGX-523

SGX-523 Chemical Structure

CAS NO. 1022150-57-7

SGX-523 is an orally bioavailable small molecule, specifically binds to c-Met protein, or HGFR, preventing binding of HGF and disrupting the MET signaling pathway.

Availability: In stock

Package Price Qty
5 mg
$40.00
10 mg
$60.00
50 mg
$180.00
100 mg
$300.00
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Biological Activity

SGX-523 is an orally bioavailable small molecule, specifically binds to c-Met protein, or HGFR, preventing binding of HGF and disrupting the MET signaling pathway.
Targets
Target Value
c-MetIC50: 4nM
B-Raf(V599E)IC50: >7μM
C-RafIC50: >7μM
AblIC50: >7μM
p38αIC50: >7μM
Abl1(Y253F)IC50: >7μM
In vitro (25°C) DMSO Warmed: 3 mg/mL (8.34 mM)
Water Insoluble
Ethanol Insoluble
In vivo 0.5% methylcellulose+0.2% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.82 mL 139.12 mL 278.24 mL
0.5 mM 5.56 mL 27.82 mL 55.65 mL
1 mM 2.78 mL 13.91 mL 27.82 mL
5 mM 0.56 mL 2.78 mL 5.56 mL

*The above data is based on the productmolecular weight 359.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10839
Actions Inhibitor
CAS No. 1022150-57-7
Formula C18H13N7S
M. Wt 359.4
Purity >98%
Synonyms SGX523
SMILES CN1C=C(C=N1)C2=NN3C(=NN=C3SC4=CC5=C(C=C4)N=CC=C5)C=C2
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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