SGX-523

Catalog No.: A10839

c-Met Inhibitor

SGX-523 Chemical Structure

CAS NO. 1022150-57-7

SGX-523 is an orally bioavailable small molecule, specifically binds to c-Met protein, or HGFR, preventing binding of HGF and disrupting the MET signaling pathway.

Availability: In stock

Package Price Qty
5 mg
$40.00
10 mg
$60.00
50 mg
$180.00
100 mg
$300.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

SGX-523 is an orally bioavailable small molecule, specifically binds to c-Met protein, or HGFR, preventing binding of HGF and disrupting the MET signaling pathway.
Targets
Target Value
c-MetIC50: 4nM
B-Raf(V599E)IC50: >7μM
C-RafIC50: >7μM
AblIC50: >7μM
p38αIC50: >7μM
Abl1(Y253F)IC50: >7μM
In vitro (25°C) DMSO 2 mg/mL (5.56 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.82 mL 139.12 mL 278.24 mL
0.5 mM 5.56 mL 27.82 mL 55.65 mL
1 mM 2.78 mL 13.91 mL 27.82 mL
5 mM 0.56 mL 2.78 mL 5.56 mL

*The above data is based on the productmolecular weight 359.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10839
Actions Inhibitor
M. Wt 359.4
Formula C18H13N7S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1022150-57-7
Synonyms SGX523
SMILES CN1C=C(C=N1)C2=NN3C(=NN=C3SC4=CC5=C(C=C4)N=CC=C5)C=C2

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