SIAIS164018 is a PROTAC-based degrader targeting ALK and EGFR, demonstrating IC50 values of 2.5 nM and 6.6 nM against ALK and ALK G1202R, respectively. This compound exhibits potent inhibitory effects on cancer cell migration and invasion, induces G1 cell cycle arrest, and promotes apoptosis. SIAIS164018 is a valuable tool for research applications investigating targeted degradation mechanisms in oncology.
SIAIS164018 is a PROTAC-based degrader targeting ALK and EGFR, demonstrating IC50 values of 2.5 nM and 6.6 nM against ALK and ALK G1202R, respectively. This compound exhibits potent inhibitory effects on cancer cell migration and invasion, induces G1 cell cycle arrest, and promotes apoptosis. SIAIS164018 is a valuable tool for research applications investigating targeted degradation mechanisms in oncology.
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