SIAIS178 is a potent and selective PROTAC BCR-ABL degrader that operates through the recruitment of Von Hippel-Lindau (VHL) E3 ubiquitin ligase, achieving an IC50 of 24 nM. This compound effectively induces degradation of the BCR-ABL protein, demonstrating significant anticancer activity. SIAIS178 is suitable for research applications focused on targeted protein degradation in cancer models.
SIAIS178 is a potent and selective PROTAC BCR-ABL degrader that operates through the recruitment of Von Hippel-Lindau (VHL) E3 ubiquitin ligase, achieving an IC50 of 24 nM. This compound effectively induces degradation of the BCR-ABL protein, demonstrating significant anticancer activity. SIAIS178 is suitable for research applications focused on targeted protein degradation in cancer models.
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