SM-164

Catalog No.: A15800

cIAP-2 antagonist

SM-164

SM-164 Chemical Structure

CAS NO. 957135-43-2

SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein with a Ki value of 0.56 nM, and binds to cIAP-1 and cIAP-2 proteins with Ki values of 0.31 and 1.1 nM, respectively.

Availability: In stock

Package Price Qty
5 mg
$280.00
10 mg
$500.00
25 mg
$1,000.00
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  • Caroline Moerke, .et al. The anticonvulsive Phenhydan® suppresses extrinsic cell death, Cell Death Differ, 2018, Nov 15 PMID: 30442947

Biological Activity

SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein with a Ki value of 0.56 nM, and binds to cIAP-1 and cIAP-2 proteins with Ki values of 0.31 and 1.1 nM, respectively.
In vitro DMSO 3 mg/mL (2.67 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 8.92 mL 44.59 mL 89.17 mL
0.5 mM 1.78 mL 8.92 mL 17.83 mL
1 mM 0.89 mL 4.46 mL 8.92 mL
5 mM 0.18 mL 0.89 mL 1.78 mL

*The above data is based on the productmolecular weight 1121.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15800
Actions Antagonist
CAS No. 957135-43-2
Formula C62H84N14O6
M. Wt 1121.42
Purity >98%
Synonyms SM 164, SM164
SMILES CC(C(=O)NC1CCCCC2CCC(N2C1=O)C(=O)NC(C3=CC=CC=C3)C4=CN(N=N4)CCCCC5=CC=C(C=C5)CCCCN6C=C(N=N6)C(C7=CC=CC=C7)NC(=O)C8CCC9N8C(=O)C(CCCC9)NC(=O)C(C)NC)NC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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