SphK1-IN-2 is a selective inhibitor targeting sphingosine kinase 1 (SphK1), exhibiting an IC50 value of 19.81 nM for SphK1 while demonstrating minimal inhibition of SphK2 (IC50 > 10 μM). This compound demonstrates anti-proliferative properties, induces cell cycle arrest, and promotes apoptosis in various cancer cell lines. SphK1-IN-2 is applicable in cancer research, providing insights into the role of sphingolipid metabolism in tumor progression and potential therapeutic strategies.
SphK1-IN-2 is a selective inhibitor targeting sphingosine kinase 1 (SphK1), exhibiting an IC50 value of 19.81 nM for SphK1 while demonstrating minimal inhibition of SphK2 (IC50 > 10 μM). This compound demonstrates anti-proliferative properties, induces cell cycle arrest, and promotes apoptosis in various cancer cell lines. SphK1-IN-2 is applicable in cancer research, providing insights into the role of sphingolipid metabolism in tumor progression and potential therapeutic strategies.
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