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SPP-DM1

Catalog No.: A41416
Drug-Linker Conjugates for ADC
SPP-DM1 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It utilizes DM1, a potent microtubule-disrupting agent, linked through the SPP linker to deliver targeted antitumor efficacy. This compound exhibits significant biological activity against malignant cells, making it relevant for cancer research and therapeutic development. SPP-DM1 is a valuable tool for studying the mechanisms of ADCs in oncology.
SPP-DM1 452072-20-7 Drug-Linker Conjugates for ADC
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Size Price Stock Qty
5mg
$560.00
In stock
10mg
$925.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSPP-DM1 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It utilizes DM1, a potent microtubule-disrupting agent, linked through the SPP linker to deliver targeted antitumor efficacy. This compound exhibits significant biological activity against malignant cells, making it relevant for cancer research and therapeutic development. SPP-DM1 is a valuable tool for studying the mechanisms of ADCs in oncology.
Product Information
Catalog NumA41416
FormulaC44H59ClN4O14S2
Molecular Weight967.54
CAS Number452072-20-7
SMILESC[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(CCSSC(C)CCC(ON5C(CCC5=O)=O)=O)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC