SU 5416 (Semaxinib)

Catalog No.: A12437

VEGFR Inhibitor

SU 5416 (Semaxinib)

SU 5416 (Semaxinib) Chemical Structure

CAS NO. 204005-46-9

SU 5416 is an inhibitor of vascular endothelial growth factor receptor (VEGFR) that also inhibits other tyrosine kinases KIT, MET, FLT3 and RET.

Availability: In stock

Package Price Qty
10 mg
$70.00
25 mg
$120.00
50 mg
$190.00
100 mg
$250.00
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  • Yin Kang, .et al. Sulforaphane Prevents Right Ventricular Injury and Reduces Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension, Am J Physiol Heart Circ Physiol, 2020, Apr 1;318(4):H853-H866 PMID: 32108526
  • Avner Adini, .et al. PR1P Stabilizes VEGF and Upregulates its Signaling to Reduce Elastase Induced Murine Emphysema, Am J Respir Cell Mol Biol, 2020, Jul 14 PMID: 32663413

Biological Activity

SU 5416 is an inhibitor of vascular endothelial growth factor receptor (VEGFR) that also inhibits other tyrosine kinases KIT, MET, FLT3 and RET.
In vitro (25°C) DMSO 19 mg/mL (79.73 mM)
Water Insoluble
Ethanol 2 mg/mL (8.39 mM)
In vivo 5% DMSO+40%PEG 300+ 5% Tween80 + ddH2O 0.4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 41.97 mL 209.84 mL 419.67 mL
0.5 mM 8.39 mL 41.97 mL 83.93 mL
1 mM 4.2 mL 20.98 mL 41.97 mL
5 mM 0.84 mL 4.2 mL 8.39 mL

*The above data is based on the productmolecular weight 238.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12437
Actions Inhibitor
CAS No. 204005-46-9
Formula C15H14N2O
M. Wt 238.28
Purity >98%
Synonyms SU-5416, SU5416
SMILES CC1=CC(=C(N1)/C=C\2/C3=CC=CC=C3NC2=O)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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