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- Guangyan Zhang, .et al. Sulforaphane Does Not Protect Right Ventricular Systolic and Diastolic Functions in Nrf2 Knockout Pulmonary Artery Hypertension Mice, Cardiovasc Drugs Ther, 2022, Feb 14 PMID: 35157168
- Michel R. Corboz, .et al. Treprostinil palmitil inhibits the hemodynamic and histopathological changes in the pulmonary vasculature and heart in an animal model of pulmonary arterial hypertension, Eur J Pharmacol, 2022, 916: 174484 PMID: 34508752
- Avner Adini, .et al. PR1P Stabilizes VEGF and Upregulates its Signaling to Reduce Elastase Induced Murine Emphysema, Am J Respir Cell Mol Biol, 2020, Jul 14 PMID: 32663413
- Yin Kang, .et al. Sulforaphane Prevents Right Ventricular Injury and Reduces Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension, Am J Physiol Heart Circ Physiol, 2020, Apr 1;318(4):H853-H866 PMID: 32108526
Biological Activity
SU 5416 is an inhibitor of vascular endothelial growth factor receptor (VEGFR) that also inhibits other tyrosine kinases KIT, MET, FLT3 and RET.
| In vitro (25°C) | DMSO | 19 mg/mL (79.73 mM) | |
| Water | Insoluble | ||
| Ethanol | 2 mg/mL (8.39 mM) | ||
| In vivo | 5% DMSO+40%PEG 300+ 5% Tween80 + ddH2O | 0.4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 41.97 mL | 209.84 mL | 419.67 mL |
| 0.5 mM | 8.39 mL | 41.97 mL | 83.93 mL |
| 1 mM | 4.2 mL | 20.98 mL | 41.97 mL |
| 5 mM | 0.84 mL | 4.2 mL | 8.39 mL |
*The above data is based on the productmolecular weight 238.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12437 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 204005-46-9 |
| Formula | C15H14N2O |
| M. Wt | 238.28 |
| Purity | >98% |
| Synonyms | SU-5416, SU5416 |
| SMILES | CC1=CC(=C(N1)/C=C\2/C3=CC=CC=C3NC2=O)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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