Tepoditamab (MCLA-117) is a bispecific monoclonal antibody engineered to target CLEC12A on myeloid cells and CD3 on cytotoxic T cells. CLEC12A is recognized as a myeloid differentiation antigen. This antibody facilitates the targeted destruction of both acute myeloid leukemia (AML) progenitor and stem cells. It achieves this through the induction of T cell-mediated cytotoxicity, leading to the proliferative lysis of AML cells. Tepoditamab (MCLA-117) is particularly valuable for research focused on the mechanisms and therapeutic interventions of acute myeloid leukemia.
Tepoditamab (MCLA-117) is a bispecific monoclonal antibody engineered to target CLEC12A on myeloid cells and CD3 on cytotoxic T cells. CLEC12A is recognized as a myeloid differentiation antigen. This antibody facilitates the targeted destruction of both acute myeloid leukemia (AML) progenitor and stem cells. It achieves this through the induction of T cell-mediated cytotoxicity, leading to the proliferative lysis of AML cells. Tepoditamab (MCLA-117) is particularly valuable for research focused on the mechanisms and therapeutic interventions of acute myeloid leukemia.
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Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
Frequently Asked Questions
What are Biosimilar Antibodies?
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research.
Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
