Terpestacin is a potent inhibitor of reactive oxygen species (ROS) production and a negative regulator of hypoxia-inducible factor 1-alpha (HIF-1α). Derived from Phoma exigua var. heteromorpha, Terpestacin binds to UQCRB, effectively impeding mitochondrial ROS generation. Its demonstrated ability to inhibit tumor angiogenesis in the FM3A breast cancer cell xenograft model highlights its relevance in cancer research, while also exhibiting notable antitumor and phytotoxic activities.
Terpestacin is a potent inhibitor of reactive oxygen species (ROS) production and a negative regulator of hypoxia-inducible factor 1-alpha (HIF-1α). Derived from Phoma exigua var. heteromorpha, Terpestacin binds to UQCRB, effectively impeding mitochondrial ROS generation. Its demonstrated ability to inhibit tumor angiogenesis in the FM3A breast cancer cell xenograft model highlights its relevance in cancer research, while also exhibiting notable antitumor and phytotoxic activities.
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