Terreic acid, a quinone epoxide antibiotic, serves as a potent inhibitor of Bruton’s tyrosine kinase (Btk) by disrupting the interaction between protein kinase C (PKC) and the pleckstrin homology domain of Btk. This compound effectively inhibits the binding of GST-BtkPH to PKC in lysates of human mast cells (HMC-1), demonstrating an IC50 value of approximately 100 μM. Its ability to modulate Btk activity makes terreic acid a valuable reagent for research applications involving immune signaling and mast cell function.
Terreic acid, a quinone epoxide antibiotic, serves as a potent inhibitor of Bruton’s tyrosine kinase (Btk) by disrupting the interaction between protein kinase C (PKC) and the pleckstrin homology domain of Btk. This compound effectively inhibits the binding of GST-BtkPH to PKC in lysates of human mast cells (HMC-1), demonstrating an IC50 value of approximately 100 μM. Its ability to modulate Btk activity makes terreic acid a valuable reagent for research applications involving immune signaling and mast cell function.
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