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Catalog No.: A21019

BTK inhibitor


Tirabrutinib Chemical Structure

CAS NO. 1351636-18-4

Tirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with an IC50 of 2.2 nM.

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Biological Activity

Tirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with an IC50 of 2.2 nM.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22 mL 110.02 mL 220.03 mL
0.5 mM 4.4 mL 22 mL 44.01 mL
1 mM 2.2 mL 11 mL 22 mL
5 mM 0.44 mL 2.2 mL 4.4 mL

*The above data is based on the productmolecular weight 454.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21019
Actions Inhibitor
CAS No. 1351636-18-4
Formula C25H22N6O3
M. Wt 454.48
Purity >98%
Synonyms ONO-4059, ONO4059, ONO 4059; GS-4059, GS 4059, GS4059
SMILES O=C1N(C2=CC=C(OC3=CC=CC=C3)C=C2)C4=C(N)N=CN=C4N1[[email protected]]5CN(C(C#CC)=O)CC5

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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