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Biological Activity
Tirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with an IC50 of 2.2 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22 mL | 110.02 mL | 220.03 mL |
| 0.5 mM | 4.4 mL | 22 mL | 44.01 mL |
| 1 mM | 2.2 mL | 11 mL | 22 mL |
| 5 mM | 0.44 mL | 2.2 mL | 4.4 mL |
*The above data is based on the productmolecular weight 454.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21019 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1351636-18-4 |
| Formula | C25H22N6O3 |
| M. Wt | 454.48 |
| Purity | >98% |
| Synonyms | ONO-4059, ONO4059, ONO 4059; GS-4059, GS 4059, GS4059 |
| SMILES | O=C1N(C2=CC=C(OC3=CC=CC=C3)C=C2)C4=C(N)N=CN=C4N1[[email protected]]5CN(C(C#CC)=O)CC5 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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