TOP1288 is a selective Src inhibitor, demonstrating potent activity against P38α, Src, and Syk kinases, with IC50 values of 116 nM, 24 nM, and 659 nM, respectively. This compound effectively inhibits the release of inflammatory cytokines from inflamed biopsies and myofibroblasts, making it a valuable tool for research on inflammation and related pathways. Its targeted action supports investigations into the modulation of kinase activity in various cellular contexts.
TOP1288 is a selective Src inhibitor, demonstrating potent activity against P38α, Src, and Syk kinases, with IC50 values of 116 nM, 24 nM, and 659 nM, respectively. This compound effectively inhibits the release of inflammatory cytokines from inflamed biopsies and myofibroblasts, making it a valuable tool for research on inflammation and related pathways. Its targeted action supports investigations into the modulation of kinase activity in various cellular contexts.
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