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Catalog No.
Product Name
Application
Product Information
Citations
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TrpAB Inhibitor
BRD-4592 is an allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase (TrpAB), specifically targeting the α-β-subunit interface. It demonstrates potent inhibitory activity, with an IC50 of 70.9 nM for the α-subunit and 22.6 nM for the β-subunit. This compound is valuable for research applications aimed at elucidating the role of tryptophan metabolism in tuberculosis and exploring novel therapeutic strategies against Mycobacterium tuberculosis. -
Proton Pump Inhibitor
AHR-9294 is a potent inhibitor of the H+ pump enzyme, specifically targeting H, K-ATPase. This compound effectively inhibits gastric acid secretion in vivo, making it valuable for research related to gastrointestinal physiology and the treatment of acid-related disorders. Its mechanism of action supports studies exploring proton pump inhibition and related therapeutic applications. -
ATPase Inhibitor
Apicularen A is a macrolide that selectively inhibits vesicular ATPases, targeting ATPase activity in cellular processes. This compound has been isolated from the mucoid bacterium Chondrosporium spp. Its potent inhibitory effects make it a valuable tool for research applications focused on cellular transport mechanisms and metabolic regulation. -
CV-B3 2C ATPase Inhibitor
ATPase-IN-8 is a selective inhibitor of CV-B3 2C ATPase, exhibiting an IC50 of 1.4 μM. This compound demonstrates significant anti-enteroviral activity, particularly against coxsackievirus B3 (CV-B3) and enterovirus D68 (EV-D68). ATPase-IN-8 is suitable for research applications focusing on enteroviral infections and their molecular mechanisms. -
ASK1 Inhibitor
ASK1-IN-10 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), exhibiting an IC50 value of less than 200 nM. In addition to its primary mechanism, ASK1-IN-10 exhibits inhibitory activity against hERG potassium channels. This compound serves as a valuable tool for investigating the role of ASK1 in inflammation-related research and its potential therapeutic implications. -
hERG Inhibitor
GSK369796 is a selective inhibitor of the hERG potassium ion channel, demonstrating an IC50 value of 7.5 μM. This compound exhibits significant antimalarial activity, making it a valuable tool for research in both cardiac function and malaria therapeutics. Its potential implications in pharmacology and drug development provide a basis for further exploration in ion channel regulation and associated biological pathways. -
H+, K+-ATPase Inhibitor
Esomeprazole magnesium salt is a selective inhibitor of the H+, K+-ATPase enzyme in gastric parietal cells, functioning as an effective proton pump inhibitor. This compound demonstrates significant biological activity by reducing gastric acid secretion. It is primarily utilized in research related to gastroesophageal reflux disease, exploring its therapeutic potential and mechanisms of action in acid-related disorders. -
Proton Pump Inhibitor
S-Pantoprazole sodium trihydrate is a potent proton pump inhibitor that effectively reduces gastric acid secretion. It is primarily utilized in the treatment of conditions associated with excessive gastric acid production, such as gastroesophageal reflux disease (GERD) and peptic ulcers. Its mechanism of action involves the irreversible inhibition of the H+/K+ ATPase enzyme in gastric parietal cells, providing therapeutic benefits in managing acid-related disorders. -
Na+-V-ATPase Inhibitor
V-161 is an orally active inhibitor of Na+-V-ATPase, exhibiting an IC50 of 144 nM. This compound effectively inhibits the growth of Enterococcus hirae and Vancomycin-resistant Enterococcus faecium (VRE) under alkaline conditions, with a minimum inhibitory concentration (MIC) of 4 µg/mL for both bacterial strains. In vivo studies demonstrate that V-161 significantly reduces VRE colonization in the mouse small intestine, making it a valuable tool for research into antimicrobial resistance and gut microbiota interactions. -
Adrenergic Receptor Inhibitor
Besipirdine is an adrenergic receptor inhibitor that exhibits non-receptor-dependent cholinomimetic properties. This compound is known to inhibit voltage-dependent sodium and potassium channels, contributing to its pharmacological profile. Besipirdine's biological activity makes it relevant for research applications focused on neuropharmacology and the modulation of synaptic transmission. -
μ-opioid Receptor Activator, hERG (Kv11.1) Potassium Channel Inhibitor
ERG-IN-6 is a potent μ-opioid receptor activator, exhibiting an EC50 of 0.12 nM, which makes it an effective tool for studies related to pain modulation. Additionally, ERG-IN-6 functions as a hERG (Kv11.1) potassium channel inhibitor with an IC50 of 0.681 μM. This compound is valuable for research applications investigating the interplay between opioid signaling and ion channel regulation. -
Calcium Channel Inhibitor
Ethacrynic acid sodium is an effective calcium channel inhibitor that primarily targets L-type voltage-dependent and store-operated calcium channels. This compound exhibits diuretic properties and significantly modulates glutathione S-transferases (GSTs) while inhibiting the NF-kB signaling pathway. Ethacrynic acid sodium demonstrates anti-inflammatory activity, evidenced by its ability to reduce retinoid-induced ear edema in murine models, making it a valuable tool in research focused on inflammation and airway smooth muscle relaxation. -
Calcium Channel Inhibitor
Levamlodipine hydrobromide is a calcium channel inhibitor with notable antioxidant and vasodilatory properties. This compound has been shown to reduce serum malondialdehyde (MDA) levels while increasing superoxide dismutase (SOD) activity, thus improving oxidative stress responses. It is appropriate for research applications related to vascular dementia, hypertension, and cerebrovascular diseases. -
TLR4/HCN Inhibitor
HCN-IN-1 is a TLR4 inhibitor and modulator of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, specifically targeting HCN2 and HCN4. It effectively inhibits TLR4-mediated signaling, evidenced by reduced alkaline phosphatase activity. HCN-IN-1 modulates HCN2 currents by shifting the voltage-dependent activation to hyperpolarized potentials and slowing activation kinetics, while also blocking currents through HCN4 channels. This compound demonstrates significant analgesic, anti-inflammatory, and anti-anginal properties, making it valuable for research into inflammatory pain, neuropathic pain, heart failure, and related inflammatory conditions. -
p97 ATPase Inhibitor
p97-IN-2 is a selective inhibitor of the p97 ATPase, with an IC50 of 0.6 μM. This compound effectively inhibits the proliferation of cancer cell lines, including HCT15 (IC50 = 1.1 μM) and SW403 (IC50 = 0.8 μM). p97-IN-2 serves as a valuable tool for investigating the role of p97 in cancer biology and therapeutic applications. -
ERAD Inhibitor
NCATS-SM0225 is an endoplasmic reticulum-associated degradation (ERAD) inhibitor that functions as a direct binder to VDAC1, VDAC2, and VDAC3. It demonstrates an IC50 of 1.02 μM for inhibiting ERAD and a Kd of 3.13 μM for binding human VDAC1. By disrupting cellular calcium homeostasis and enhancing VDAC1-IP3R coupling, NCATS-SM0225 activates the PERK pathway and selectively induces apoptosis in cancer cells. This reagent is valuable for investigating cancer biology, particularly in melanoma, as well as exploring the underlying mechanisms of ERAD and calcium homeostasis regulation. -
Serotonin And Norepinephrine Reuptake Inhibitor
Milnacipran is an orally active serotonin and norepinephrine reuptake inhibitor that primarily targets the monoamine transporters responsible for neurotransmitter reuptake. It demonstrates high affinity for the norepinephrine transporter and serotonin transporter, with Ki values of 31 nM and 8.5 nM, respectively. Milnacipran exhibits antidepressant, anxiolytic, and analgesic properties, and has been shown to inhibit pERK1/2 activation. This compound is applicable in the study of major depressive disorder, anxiety disorders, and neuropathic pain conditions such as fibromyalgia. -
RAD51 Inhibitor
DIDS is a RAD51 inhibitor that disrupts RAD51-mediated homologous pairing and strand exchange reactions, thereby impacting DNA repair processes. In addition to its primary function, DIDS also inhibits ABCA1 and VDAC1, affecting anion exchange and binding to red blood cell membranes. Furthermore, it has been shown to inhibit the activation of caspase-3 and -9, making it a valuable tool for cancer research applications. -
Proton Pump Inhibitor
Ilaprazole sodium hydrate is a potent proton pump inhibitor that irreversibly targets H+/K+-ATPase, exhibiting an IC50 value of 6 μM in rabbit parietal cell preparations. This compound is primarily utilized in research related to gastric ulcers, providing insights into gastric acid secretion and its regulation. In addition, Ilaprazole sodium hydrate demonstrates inhibitory activity against TOPK (T-lymphokine-activated killer cell-originated protein kinase), making it a valuable tool for studies on cellular signaling pathways and cancer research. -
TRPV1 Inhibitor
(±)-Eriodictyol is a potent TRPV1 receptor antagonist, exhibiting an IC50 value of 44-47 nM in rTRPV1 assays. This compound demonstrates significant antioxidant and anti-inflammatory properties, effectively inhibiting lipid peroxidation and reducing the release of proinflammatory cytokines. By modulating the Nrf2 signaling pathway, (±)-Eriodictyol helps maintain the integrity of the blood-retinal barrier and can alleviate oxidative stress-induced apoptosis and hyperalgesia. It has potential applications in the research of diabetic retinopathy, acute lung injury, and various pain-related conditions, while also enhancing immune cell activity and promoting antioxidant enzyme levels. -
Furin Inhibitor
BOS-318 is a highly selective and cell-permeable inhibitor of furin, exhibiting an IC50 value of 1.9 nM. This compound demonstrates the ability to protect epithelial sodium channels (ENaC) from activation by neutrophil elastase. BOS-318 is a valuable tool for research focused on cystic fibrosis and related pulmonary conditions. -
Serotonin Transporter Inhibitor
Lubazodone hydrochloride is a selective serotonin transporter inhibitor that primarily modulates serotonin levels in the central nervous system. Its biological activity is associated with antidepressant effects, making it a valuable compound for research into the treatment of depression and related mood disorders. This reagent can aid in the exploration of serotonin dynamics and its implications in various neurobiological studies. -
Serotonin Reuptake Inhibitor
Citalopram is a selective serotonin reuptake inhibitor (SSRI) that primarily targets the serotonin transporter, resulting in increased serotonergic neurotransmission. This compound is utilized for its antidepressant properties and is effective in the treatment of major depressive disorder and anxiety-related conditions. Research applications include studies on mood regulation and neurotransmitter dynamics. -
Serotonin Transporter Inhibitor
Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) that targets the serotonin transporter. It is primarily used in the treatment of obsessive-compulsive disorder and depression by increasing serotonin levels in the synaptic cleft. This compound is valuable in research applications exploring mood regulation, anxiety disorders, and the neural mechanisms underlying depression. -
SERT Inhibitor
SERT-IN-2 is a potent serotonin transporter (SERT) inhibitor, demonstrating an IC50 of 0.58 nM. This compound exhibits significant anti-depressive activity and shows a high bioavailability of 83.28% in rat models. Additionally, SERT-IN-2 possesses the ability to cross the blood-brain barrier, making it a valuable tool for research into mood disorders and related pharmacological studies. -
Serotonin Reuptake Inhibitor
(S)-Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor (SSRI) primarily utilized in the treatment of major depressive disorder and anxiety disorders. By increasing serotonin levels in the brain, it enhances mood and alleviates symptoms of depression. This compound is frequently employed in pharmacological studies related to depression, anxiety, and other mood disorders, making it valuable for researchers exploring therapeutic interventions in neuropsychology. -
NET/SERT Inhibitor
Desmethyl Sibutramine hydrochloride is a potent norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. As a secondary metabolite of Sibutramine, it plays a significant role in modulating neurotransmitter levels associated with appetite regulation. This compound is utilized in research focused on obesity and the development of appetite suppressant therapies. -
NET/SERT Inhibitor
Ampreloxetine hydrochloride is an orally active inhibitor of the norepinephrine transporter (NET) and serotonin transporter (SERT), with no activity against the dopamine transporter (DAT). It shows binding affinities with EC50 values of 11.7 ng/mL for NET and 50.8 ng/mL for SERT in plasma. This compound is utilized in research related to mood disorders and anxiety, offering insights into the modulation of norepinephrine and serotonin levels within the central nervous system. -
Serotonin Reuptake Inhibitor
(R)-Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor (SSRI) primarily targeting the serotonin transporter. This compound demonstrates a modest affinity for the 5-HT2A and 5-HT2C receptors, contributing to its pharmacological profile. It is widely utilized in research related to depression, anxiety disorders, and other serotonin-related dysfunctions. -
Serotonin Transporter Inhibitor
Dapoxetine-d7 hydrochloride is a deuterium-labeled derivative of Dapoxetine hydrochloride, specifically targeting the serotonin transporter. This compound acts as a selective serotonin reuptake inhibitor (SSRI) with a short duration of action. Dapoxetine-d7 hydrochloride is employed in pharmacokinetic studies, providing insights into the metabolism and distribution of SSRIs in biological systems. -
NET/SERT Inhibitor
Desmethyl Sibutramine is an orally active inhibitor of the norepinephrine transporter (NET) and serotonin transporter (SERT). This compound demonstrates significant biological activity in modulating neurotransmitter levels, making it a valuable tool in obesity research and the study of appetite suppression mechanisms. Its metabolic profile and pharmacological effects contribute to its utility in understanding weight management therapies. -
Serotonin Transporter Inhibitor
Wy-45494 hydrochloride is a potent serotonin transporter inhibitor deriving from the selective norepinephrine and serotonin reuptake inhibitor venlafaxine, primarily formed via cytochrome P450 CYP3A4 metabolism. This compound demonstrates significant biological activity by inhibiting norepinephrine and serotonin reuptake, with IC50 values of 4.7 μM and 1.6 μM, respectively, in rat synaptosomal preparations. In animal studies, it effectively reverses reserpine-induced hypothermia in mice, establishing its potential utility in research related to mood disorders and neurotransmitter regulation. -
Serotonin-norepinephrine Reuptake Inhibitor
Ansofaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that plays a critical role in investigating the pathophysiology of depression and related mood disorders. By modulating the levels of serotonin and norepinephrine in the synaptic cleft, Ansofaxine enhancing neurotransmitter availability and activity. This compound is valuable for research applications focused on the mechanisms of action of SNRIs in the treatment of depression and for exploring new therapeutic strategies. -
SSRI Inhibitor
Paroxetine maleate is a selective serotonin reuptake inhibitor (SSRI) that primarily targets the serotonin transporter (SERT). It exhibits significant efficacy in modulating serotonergic activity, making it valuable in the study of mood and anxiety disorders. Paroxetine maleate is commonly utilized in research related to generalized anxiety disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, and chronic headache conditions. -
Serotonin Transporter Inhibitor
(R)-Duloxetine hydrochloride is a selective serotonin transporter inhibitor primarily used in pharmacological studies. It demonstrates significant binding affinity and is of interest in investigations related to serotonin reuptake mechanisms. Unlike its enantiomer (S)-Duloxetine, (R)-Duloxetine has limited effectiveness as a dual reuptake inhibitor for serotonin and norepinephrine, making it a valuable compound for research on monoaminergic neurotransmission and related disorders. -
NE Reuptake Inhibitor
Tampramine fumarate is a potent and selective noncompetitive inhibitor of norepinephrine (NE) reuptake. This compound exhibits significant antidepressant activity, making it a valuable tool for studying depression and its related mechanisms. Researchers can utilize Tampramine fumarate to investigate the role of NE reuptake inhibition in neuropharmacology and the development of antidepressant therapies. -
Serotonin Transporter Inhibitor
Nitroxazepine hydrochloride is a potent serotonin transporter inhibitor functioning as a tricyclic antidepressant (TCA). It enhances serotonergic and noradrenergic neurotransmission by inhibiting the reuptake of serotonin and norepinephrine, making it a valuable compound for research into the mechanisms of depression and related mood disorders. Its role in modulating serotonin levels also provides insights into the pharmacological treatment options for various psychiatric conditions. -
Serotonin Re-uptake Inhibitor
(R)-Norfluoxetine is the (R)-enantiomer of Norfluoxetine, acting as a potent serotonin reuptake inhibitor, with a Ki of 13 nM. This compound is primarily utilized in research focusing on the pathophysiology and treatment of depression. Its selective inhibition of serotonin reuptake makes it an essential tool for studying serotonergic signaling and therapeutic interventions in mood disorders. -
Serotonin Reuptake Inhibitor
Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) that is orally active. It has been primarily investigated for its biological activity in the treatment of premature ejaculation (PE). Dapoxetine's mechanism of action enhances serotonergic signaling, contributing to increased ejaculatory control and prolonged intravaginal ejaculatory latency. This makes Dapoxetine a valuable reagent in sexual health research and studies focused on sexual dysfunction. -
Norepinephrine Reuptake Inhibitor
Tametraline is a norepinephrine reuptake inhibitor that modulates the levels of norepinephrine in the synaptic cleft. This compound exhibits significant antidepressant activity and is primarily utilized in research investigating neurological disorders, particularly depression. Its mechanism of action may provide insights into the treatment and understanding of mood-related pathologies. -
SerT Inhibitor
SERT-IN-3 is a potent inhibitor of the serotonin transporter (SerT), displaying an IC50 value of 34.4 nM in pharmacological assays. This compound plays a critical role in research applications focused on serotonin modulation, making it a valuable tool for studying neuropharmacology and potential therapeutic interventions in mood and anxiety disorders. -
Serotonin Transporter Inhibitor
(±)-Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor targeting the serotonin transporter. This compound exhibits significant analgesic and antidepressant properties, making it valuable in studies related to diabetic neuropathic pain, fibromyalgia, and major depressive disorder. Researchers utilize (±)-Duloxetine hydrochloride to explore its potential therapeutic effects and underlying mechanisms in various neuropathic and mood disorders. -
Serotonin Transporter Inhibitor
(S)-Venlafaxine is a potent serotonin transporter inhibitor that also affects norepinephrine reuptake. This compound is recognized for its antidepressant properties and is utilized in research to investigate mechanisms of mood disorders and neuropharmacology. Its dual inhibitory action on 5-HT and NE transporters makes it a valuable tool for studying depression and anxiety-related pathways. -
Dual Serotonin and Noradrenaline Monoamine reuptake Inhibitor
SNRI-IN-1 is a dual serotonin and noradrenaline monoamine reuptake inhibitor that demonstrates significant activity in modulating neurotransmitter levels. With a P-glycoprotein Efflux Ratio of 20, this compound is useful in studying the dynamics of monoamine transport and its implications in mood disorders and cognitive function. Research applications include investigating the effects of dual inhibition on neurotransmission and potential therapeutic benefits in conditions such as depression and anxiety. -
Serotonin-norepinephrine Reuptake Inhibitor
Duloxetine-d3 hydrochloride is a deuterium-labeled derivative of Duloxetine hydrochloride, functioning as a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM. This compound is primarily utilized in research to study the pharmacokinetics and biological effects of Duloxetine in models of major depressive disorder and generalized anxiety disorder. Its stable isotope labeling enables precise tracking in metabolic studies and enhances the understanding of drug metabolism and action mechanisms. -
5-hydroxytryptamine Uptake Inhibitor
Serotonin azidobenzamidine is a selective inhibitor of 5-hydroxytryptamine (serotonin) uptake, functioning through competitive inhibition. It demonstrates significant biological activity with a Ki value of 130 nM, effectively inhibiting [3H]5-hydroxytryptamine uptake in rat cortical synaptosomes. This reagent is valuable in neuropharmacological research, aiding in the study of serotonin modulation and its effects on various physiological processes. -
Serotonin Transporter Inhibitor
(S)-Tomoxetine hydrochloride is a selective serotonin transporter inhibitor known for its ability to modulate serotonin levels in synaptic clefts. With a reported inhibition constant (Ki) of 16.8 nM, it effectively inhibits the reuptake of norepinephrine, thereby influencing neurotransmitter dynamics. This compound is utilized in research focused on neuropharmacology, mood disorders, and the mechanisms of serotonin signaling. -
Serotonin Reuptake Inhibitor
(S)-Norfluoxetine is a selective serotonin reuptake inhibitor that primarily targets the serotonin transporter. It has been shown to enhance allopregnanolone levels and decrease aggressive behavior in socially isolated murine models. This compound is valuable in research related to neuropharmacology and the understanding of mood and anxiety disorders. -
SERT Inhibitor
Nardosinonediol is a selective serotonin transporter (SERT) inhibitor. It demonstrates significant modulation of serotonin uptake, making it a valuable tool for studying serotonin-related pathways. This compound is primarily used in research focused on neuropharmacology, mood disorders, and the development of antidepressant therapies. -
Serotonin Reuptake Inhibitor
(Rac)-Dapoxetine hydrochloride is a racemic mixture of Dapoxetine hydrochloride, a selective serotonin reuptake inhibitor (SSRI) that primarily targets serotonin transporters. This compound exhibits notable efficacy in the treatment of premature ejaculation (PE) and is valuable in research aimed at understanding this condition. Its pharmacological profile positions it as a significant tool for studying serotonin-related pathways in human sexual health.
