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Catalog No.: A14222

Mcl-1 inhibitor


UMI-77 Chemical Structure

CAS NO. 518303-20-3

UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family.

Availability: In stock

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5 mg
10 mg
25 mg
10mM * 1mL in DMSO
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Biological Activity

UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family.
490 nM(Ki)
In vitro (25°C) DMSO 92 mg/mL (196.43 mM)
Water Insoluble
Ethanol Warmed: 92 mg/mL (196.43 mM)
In vivo 5% DMSO+30% PEG 300+dd H2O 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.35 mL 106.76 mL 213.52 mL
0.5 mM 4.27 mL 21.35 mL 42.7 mL
1 mM 2.14 mL 10.68 mL 21.35 mL
5 mM 0.43 mL 2.14 mL 4.27 mL

*The above data is based on the productmolecular weight 468.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14222
Actions Inhibitor
CAS No. 518303-20-3
Formula C18H14BrNO5S2
M. Wt 468.34
Purity >98%
Synonyms UMI 77,UMI77
SMILES C1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=C(C=C3)Br

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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